Tbio LMAN1 Protein ERGIC-53

Protein Summary

Description

Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency. [provided by RefSeq, Jul 2015]

Uniprot Accession IDs

• P49257
• Q12895
• Q8N5I7
• Q9UQG1
• Q9UQG2
• Q9UQG3
• Q9UQG4
• Q9UQG5
• Q9UQG6
• Q9UQG7
• Q9UQG8
• Q9UQG9
• Q9UQH0
• Q9UQH1
• Q9UQH2

Gene Name

• LMAN1

Ensembl ID

• ENST00000251047
• ENSP00000251047
• ENSG00000074695

Symbol

• ERGIC53
• F5F8D
• MR60
• gp58
• F5F8D
• FMFD1
• MCFD1
• ERGIC53
• ERGIC-53

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.84
histone modification site profile	0.77
virus perturbation	0.76
cellular component	0.75
small molecule perturbation	0.7

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Protein Ergic-53

DTO Classes

Protein / Transporter / Protein Ergic-53

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.68   (req: < 5)

Gene RIFs: 52   (req: <= 3)

Antibodies: 238   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.68   (req: >= 5)

Gene RIFs: 52   (req: > 3)

Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0