Protein Summary
Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency. [provided by RefSeq, Jul 2015]
- ENST00000251047
- ENSP00000251047
- ENSG00000074695
- ERGIC53
- F5F8D
- MR60
- gp58
- F5F8D
- FMFD1
- MCFD1
- ERGIC53
- ERGIC-53
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.84 | ||
histone modification site profile | 0.77 | ||
virus perturbation | 0.76 | ||
cellular component | 0.75 | ||
small molecule perturbation | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 169.38 (req: < 5)
Gene RIFs: 47 (req: <= 3)
Antibodies: 238 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 169.38 (req: >= 5)
Gene RIFs: 47 (req: > 3)
Antibodies: 238 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (158)
GINM1
Novelty: 1.0701107
p_int: 0.84043376
p_ni: 0.15956624
Score: 0.221
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (23)
Reactome (9)
KEGG (1)
PathwayCommons (1)
WikiPathways (12)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | COPII-mediated vesicle transport | ||||
Reactome | Cargo concentration in the ER | ||||
Reactome | ER to Golgi Anterograde Transport | ||||
Reactome | Membrane Trafficking | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Asparagine N-linked glycosylation | ||||
COPII-mediated vesicle transport | ||||
Cargo concentration in the ER | ||||
ER to Golgi Anterograde Transport | ||||
Membrane Trafficking | ||||
Viral Interactions (0)
Gene Ontology Terms (25)
Functions (3)
Components (13)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
cardiac troponin I measurement | 1 | 1 | 1 | 50.6 | |||||
IGF-1 measurement | 1 | 1 | 1 | 10.4 | |||||
eosinophil count | 1 | 1 | 1 | 7.2 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
cardiac troponin I measurement | 1 | 50.6 | |||||
IGF-1 measurement | 1 | 10.4 | |||||
eosinophil count | 1 | 7.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | lectin, mannose binding 1 | VGNC:10016 | 455448 | |||||
Macaque | lectin, mannose binding 1 | 697449 | ||||||
Mouse | MGI:1917611 | 70361 | ||||||
Rat | RGD:71020 | 116666 | ||||||
Dog | lectin, mannose binding 1 | VGNC:42706 | 476186 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | lectin, mannose binding 1 | |||||
Macaque | lectin, mannose binding 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | lectin, mannose binding 1 | |||||
Publication Statistics
PubMed Score 169.38
PubMed score by year
PubTator Score 141.99
PubTator score by year
Related Publications
Text Mined References (82)
GeneRif Annotations (47)
Items per page:
0 of 0
PMID | Year | Title |
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