Tbio LMAN1 Protein ERGIC-53

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Protein Ergic-53

DTO Classes

Protein / Transporter / Protein Ergic-53

Protein Summary

Description

Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency. [provided by RefSeq, Jul 2015]

Uniprot Accession IDs

• P49257
• Q12895
• Q8N5I7
• Q9UQG1
• Q9UQG2
• Q9UQG3
• Q9UQG4
• Q9UQG5
• Q9UQG6
• Q9UQG7
• Q9UQG8
• Q9UQG9
• Q9UQH0
• Q9UQH1
• Q9UQH2

Gene Name

• LMAN1

Ensembl ID

• ENST00000251047
• ENSP00000251047
• ENSG00000074695

Symbol

• ERGIC53
• F5F8D
• MR60
• gp58
• F5F8D
• FMFD1
• MCFD1
• ERGIC53
• ERGIC-53

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.84
histone modification site profile	0.77
virus perturbation	0.76
cellular component	0.75
small molecule perturbation	0.7

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.71   (req: < 5)

Gene RIFs: 47   (req: <= 3)

Antibodies: 238   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.71   (req: >= 5)

Gene RIFs: 47   (req: > 3)

Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cardiac troponin I measurement	EFO_0010071	1	1	1		62.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cardiac troponin I measurement	EFO_0010071	1		62.5

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Protein Data Bank (11)

1 – 5 of 11

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (23)

Reactome (9)

KEGG (1)

PathwayCommons (1)

WikiPathways (12)

Asparagine N-linked glycosylation (R-HSA-446203)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Asparagine N-linked glycosylation	286 targets	R-HSA-446203
Reactome	COPII-mediated vesicle transport	68 targets	R-HSA-204005
Reactome	Cargo concentration in the ER	33 targets	R-HSA-5694530
Reactome	ER to Golgi Anterograde Transport	136 targets	R-HSA-199977
Reactome	Membrane Trafficking	612 targets	R-HSA-199991

Name	Explore in Pharos	Explore in Source
Asparagine N-linked glycosylation	286 targets	R-HSA-446203
COPII-mediated vesicle transport	68 targets	R-HSA-204005
Cargo concentration in the ER	33 targets	R-HSA-5694530
ER to Golgi Anterograde Transport	136 targets	R-HSA-199977
Membrane Trafficking	612 targets	R-HSA-199991

Gene Ontology Terms (25)

Functions (3)

Components (13)

Processes (9)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
mannose binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
unfolded protein binding	Traceable Author Statement (TAS)	ProtInc
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (158)

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1 – 10 of 158

• See Interactions on String-DB

GINM1

Tdark

Novelty: 1.0701107

p_int: 0.84043376

p_ni: 0.15956624

Score: 0.221

Data Source: BioPlex,STRINGDB

MCFD2

Tbio

Novelty: 0.0402944

Score: 0.999

Data Source: Reactome,STRINGDB

SEC31A

Tbio

Novelty: 0.0350228

Score: 0.979

Data Source: STRINGDB

SEC24C

Tbio

Novelty: 0.05842956

Score: 0.978

Data Source: STRINGDB

F8

Tbio

Novelty: 0.0002287

Score: 0.976

Data Source: Reactome,STRINGDB

SEC13

Tbio

Novelty: 0.00709413

Score: 0.976

Data Source: STRINGDB

STX5

Tbio

Novelty: 0.00964918

Score: 0.976

Data Source: STRINGDB

SEC23A

Tbio

Novelty: 0.0384262

Score: 0.975

Data Source: STRINGDB

SEC22B

Tbio

Novelty: 0.03035448

Score: 0.974

Data Source: STRINGDB

SEC16A

Tbio

Novelty: 0.02221416

Score: 0.972

Data Source: STRINGDB

Publication Statistics

PubMed Score  167.71

PubMed score by year

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PubTator Score  141.99

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Complete proteome
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
ER-Golgi transport
Golgi apparatus
Lectin
Membrane
Metal-binding

GWAS Trait Find Similar Targets

cardiac troponin I measurement

MGI Phenotype Find Similar Targets

cellular phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
mortality/aging