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Tbio
RPIA
Ribose-5-phosphate isomerase

Protein Summary
Description
The protein encoded by this gene is an enzyme, which catalyzes the reversible conversion between ribose-5-phosphate and ribulose-5-phosphate in the pentose-phosphate pathway. This gene is highly conserved in most organisms. The enzyme plays an essential role in the carbohydrate metabolism. Mutations in this gene cause ribose 5-phosphate isomerase deficiency. A pseudogene is found on chromosome 18. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283646
  • ENSP00000283646
  • ENSG00000153574

Symbol
  • RPI
  • RPI
  • RPIAD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.96
transcription factor binding site profile
0.96
transcription factor perturbation
0.88
histone modification site profile
0.87


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.36   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.36   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribose 5-phosphate isomerase A
VGNC:360
470428
Macaque
ribose 5-phosphate isomerase A
699694
Mouse
MGI:103254
19895
Rat
RGD:1311377
362383
Dog
ribose-5-phosphate isomerase
475755
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribose 5-phosphate isomerase A
Macaque
ribose 5-phosphate isomerase A
Mouse
Rat
Dog
ribose-5-phosphate isomerase
Pathways (20)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of carbohydrate metabolism
Reactome
Diseases of metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Disease
Diseases of carbohydrate metabolism
Diseases of metabolism
Metabolism
Metabolism of carbohydrates
Protein-Protein Interactions (153)
1 – 10 of 153
WDR5B
Tdark
Novelty: 1.29746249
p_int: 0.999999782
p_ni: 2.18e-7
p_wrong: 1e-9
Score: 0.167
Data Source: BioPlex,STRINGDB
DHH
Tbio
Novelty: 0.00329784
p_int: 0.999998815
p_ni: 0.000001185
Score: 0.228
Data Source: BioPlex,STRINGDB
PCMT1
Tbio
Family: Enzyme
Novelty: 0.01414946
p_int: 0.999996678
p_ni: 0.000003298
p_wrong: 2.4e-8
Score: 0.231
Data Source: BioPlex,STRINGDB
ST8SIA1
Tbio
Family: Enzyme
Novelty: 0.02322808
p_int: 0.999518409
p_ni: 0.000481588
p_wrong: 3e-9
Score: 0.196
Data Source: BioPlex,STRINGDB
TRPV5
Tchem
Family: IC
Novelty: 0.0055156
p_int: 0.995142468
p_ni: 0.002894207
p_wrong: 0.001963326
Score: 0.19
Data Source: BioPlex,STRINGDB
ERP44
Tbio
Novelty: 0.02352693
p_int: 0.972718541
p_ni: 0.026698064
p_wrong: 0.000583395
Score: 0.365
Data Source: BioPlex,STRINGDB
MARK4
Tchem
Family: Kinase
Novelty: 0.01908376
p_int: 0.958489705
p_ni: 0.040983526
p_wrong: 0.00052677
Score: 0.309
Data Source: BioPlex,STRINGDB
AURKA
Tchem
Family: Kinase
Novelty: 0.0010868
p_int: 0.75063442
p_ni: 0.245710538
p_wrong: 0.003655042
Data Source: BioPlex
TKT
Tchem
Family: Enzyme
Novelty: 0.00333936
Score: 0.993
Data Source: STRINGDB
RPE
Tbio
Family: Enzyme
Novelty: 0.01035554
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score  102.36

PubMed score by year
PubTator Score  44.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer