Tchem CX3CR1 CX3C chemokine receptor 1

Protein Summary

Description

Receptor for the CX3C chemokine fractalkine (CX3CL1); binds to CX3CL1 and mediates both its adhesive and migratory functions (PubMed:9390561, PubMed:23125415). Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro) (PubMed:9726990). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1 (PubMed:14607932). Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Uniprot Accession IDs

• P49238
• A0N0N6
• B2R5Z4
• J3KP17
• C-X3-C CKR-1

Gene Name

• CX3CR1

Ensembl ID

• ENST00000358309
• ENSP00000351059
• ENSG00000168329
• ENST00000399220
• ENSP00000382166
• ENST00000541347
• ENSP00000439140
• ENST00000542107
• ENSP00000444928

Symbol

• CMKBRL1
• GPR13
• V28
• CCRL1
• GPR13
• CMKDR1
• GPRV28
• CMKBRL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.97
PubMedID	0.96
biological process	0.82
phenotype	0.76
disease	0.74

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Chemokine Receptor / C-x3-c Chemokine Receptor / Cx3c Chemokine Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1178.33   (req: < 5)

Gene RIFs: 271   (req: <= 3)

Antibodies: 679   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1178.33   (req: >= 5)

Gene RIFs: 271   (req: > 3)

Antibodies: 679   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 43

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0