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Tbio
RPL34
60S ribosomal protein L34

Protein Summary
Description
Component of the large ribosomal subunit. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L34E family of ribosomal proteins. It is located in the cytoplasm. This gene originally was thought to be located at 17q21, but it has been mapped to 4q. Overexpression of this gene has been observed in some cancer cells. Alternative splicing results in multiple transcript variants, all encoding the same isoform. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394665
  • ENSP00000378160
  • ENSG00000109475
  • ENST00000394667
  • ENSP00000378162
  • ENST00000394668
  • ENSP00000378163
  • ENST00000502534
  • ENSP00000423983
  • ENST00000506397
  • ENSP00000423316

Symbol
  • L34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.83
interacting protein
0.79
cellular component
0.78
biological process
0.71
transcription factor binding site profile
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.32   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.32   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
1
1
0
1.1
72.6
apolipoprotein A 1 measurement
1
1
1
2
low density lipoprotein cholesterol measurement
1
1
1
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
72.6
apolipoprotein A 1 measurement
1
2
low density lipoprotein cholesterol measurement
1
1.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L34
VGNC:12968
461427
Mouse
MGI:1915686
68436
Rat
RGD:1309402
362041
Horse
ribosomal protein L34
100072913
Cow
ribosomal protein L34
VGNC:34116
505603
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L34
Mouse
Rat
Horse
ribosomal protein L34
Cow
ribosomal protein L34
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49207-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (424)
1 – 10 of 424
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.953938572
p_ni:  0.046061366
p_wrong:  6.2e-8
Score:  0.598
Data Source:  BioPlex,STRINGDB
RPL24
Tbio
Novelty:  0.02160548
Score:  0.999
Data Source:  STRINGDB
RPS16
Tbio
Novelty:  0.00261983
Score:  0.999
Data Source:  STRINGDB
RPL8
Tbio
Novelty:  0.01064076
Score:  0.999
Data Source:  STRINGDB
RPL13A
Tbio
Novelty:  0.00503698
Score:  0.999
Data Source:  STRINGDB
RPS13
Tbio
Novelty:  0.0019983
Score:  0.999
Data Source:  STRINGDB
RPL7A
Tbio
Novelty:  0.01674027
Score:  0.999
Data Source:  STRINGDB
RPLP1
Tbio
Novelty:  0.01471148
Score:  0.999
Data Source:  STRINGDB
RPS5
Tbio
Novelty:  0.00513677
Score:  0.999
Data Source:  STRINGDB
RPS2
Tbio
Novelty:  0.00412313
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  46.32

PubMed score by year
PubTator Score  585.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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