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Tbio
RPL34
60S ribosomal protein L34

Protein Summary
Description
Component of the large ribosomal subunit. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L34E family of ribosomal proteins. It is located in the cytoplasm. This gene originally was thought to be located at 17q21, but it has been mapped to 4q. Overexpression of this gene has been observed in some cancer cells. Alternative splicing results in multiple transcript variants, all encoding the same isoform. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394665
  • ENSP00000378160
  • ENSG00000109475
  • ENST00000394667
  • ENSP00000378162
  • ENST00000394668
  • ENSP00000378163
  • ENST00000502534
  • ENSP00000423983
  • ENST00000506397
  • ENSP00000423316

Symbol
  • L34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.83
interacting protein
0.79
cellular component
0.78
biological process
0.71
transcription factor binding site profile
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.32   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.32   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (424)
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.953938572
p_ni:  0.046061366
p_wrong:  6.2e-8
Score:  0.598
Data Source:  BioPlex,STRINGDB
RPS13
Tbio
Novelty:  0.0019983
Score:  0.999
Data Source:  STRINGDB
RPS16
Tbio
Novelty:  0.00261983
Score:  0.999
Data Source:  STRINGDB
RPL13A
Tbio
Novelty:  0.00503698
Score:  0.999
Data Source:  STRINGDB
RPL8
Tbio
Novelty:  0.01064076
Score:  0.999
Data Source:  STRINGDB
RPL24
Tbio
Novelty:  0.02160548
Score:  0.999
Data Source:  STRINGDB
RPL7A
Tbio
Novelty:  0.01674027
Score:  0.999
Data Source:  STRINGDB
RPLP1
Tbio
Novelty:  0.01471148
Score:  0.999
Data Source:  STRINGDB
RPS5
Tbio
Novelty:  0.00513677
Score:  0.999
Data Source:  STRINGDB
RPS3A
Tbio
Novelty:  0.01009445
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
1
1
0
1.1
72.6
apolipoprotein A 1 measurement
1
1
1
2
low density lipoprotein cholesterol measurement
1
1
1
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
72.6
apolipoprotein A 1 measurement
1
2
low density lipoprotein cholesterol measurement
1
1.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L34
VGNC:12968
461427
Mouse
MGI:1915686
68436
Rat
RGD:1309402
362041
Horse
ribosomal protein L34
100072913
Cow
ribosomal protein L34
VGNC:34116
505603
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L34
Mouse
Rat
Horse
ribosomal protein L34
Cow
ribosomal protein L34
Publication Statistics
PubMed Score 46.32
PubMed score by year
PubTator Score 585.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title