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Tchem
PTH2R
Parathyroid hormone 2 receptor

Protein Summary
Description
This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity). The protein encoded by this gene is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272847
  • ENSP00000272847
  • ENSG00000144407

Symbol
  • PTHR2
  • PTHR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.78
gene perturbation
0.66
virus perturbation
0.64
protein domain
0.58
histone modification site profile
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.61   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.61   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
teriparatide
Rendered image for teriparatide
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip bone mineral density
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip bone mineral density
1
29
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
parathyroid hormone 2 receptor
VGNC:2792
470631
Macaque
parathyroid hormone 2 receptor
710383
Mouse
MGI:2180917
213527
Rat
RGD:620612
81753
Dog
parathyroid hormone 2 receptor
VGNC:45156
609846
Species
Name
OMA
EggNOG
Inparanoid
Chimp
parathyroid hormone 2 receptor
Macaque
parathyroid hormone 2 receptor
Mouse
Rat
Dog
parathyroid hormone 2 receptor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P49190-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Protein-Protein Interactions (139)
1 – 10 of 139
PTH2
Tdark
Novelty:  0.0288995
Score:  0.992
Data Source:  Reactome,STRINGDB
PTH
Tbio
Novelty:  0.00003263
Score:  0.978
Data Source:  Reactome,STRINGDB
PTHLH
Tbio
Novelty:  0.00050137
Score:  0.974
Data Source:  Reactome,STRINGDB
CRH
Tbio
Novelty:  0.000147
Score:  0.955
Data Source:  STRINGDB
CALCA
Tbio
Novelty:  0.00010496
Score:  0.954
Data Source:  STRINGDB
CALCA
Tclin
Novelty:  0.00010496
Score:  0.954
Data Source:  STRINGDB
SCT
Tbio
Novelty:  0.00070278
Score:  0.947
Data Source:  STRINGDB
ADCYAP1
Tbio
Family:  Enzyme
Novelty:  0.00080219
Score:  0.943
Data Source:  STRINGDB
VIP
Tbio
Novelty:  0.00024946
Score:  0.943
Data Source:  STRINGDB
GHRH
Tbio
Novelty:  0.00058152
Score:  0.936
Data Source:  STRINGDB
Publication Statistics
PubMed Score  30.61

PubMed score by year
PubTator Score  28.53

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer