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Tbio
ALDH9A1
4-trimethylaminobutyraldehyde dehydrogenase

Protein Summary
Description
Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction. This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354775
  • ENSP00000346827
  • ENSG00000143149
  • ENST00000538148
  • ENSP00000440026

Symbol
  • ALDH4
  • ALDH7
  • ALDH9
  • E3
  • ALDH4
  • ALDH7
  • ALDH9
  • TMABADH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
disease perturbation
0.96
kinase perturbation
0.91
protein domain
0.85
molecular function
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.31   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 226   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.31   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
9
8
13
99
4
3
0
1.4
95.7
4
3
0
1.4
94.5
Antiglaucoma preparations and miotics use measurement
1
1
1
82.3
granulocyte count
1
1
1
5.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
13
99
0
1.4
95.7
0
1.4
94.5
Antiglaucoma preparations and miotics use measurement
1
82.3
granulocyte count
1
5.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aldehyde dehydrogenase 9 family member A1
VGNC:75
457478
Macaque
aldehyde dehydrogenase 9 family member A1
695383
Mouse
MGI:1861622
56752
Rat
RGD:68409
64040
Dog
aldehyde dehydrogenase 9 family member A1
VGNC:37791
478991
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aldehyde dehydrogenase 9 family member A1
Macaque
aldehyde dehydrogenase 9 family member A1
Mouse
Rat
Dog
aldehyde dehydrogenase 9 family member A1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P49189-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (29)
Carnitine synthesis (R-HSA-71262)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carnitine synthesis
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Carnitine synthesis
Metabolism
Metabolism of amino acids and derivatives
Gene Ontology Terms (14)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (82)
1 – 10 of 82
ADH5
Tchem
Family:  Enzyme
Novelty:  0.00248968
Score:  0.968
Data Source:  STRINGDB
ABAT
Tclin
Family:  Enzyme
Novelty:  0.0078359
Score:  0.953
Data Source:  STRINGDB
BBOX1
Tchem
Family:  Enzyme
Novelty:  0.00255489
Score:  0.951
Data Source:  STRINGDB
AKR1A1
Tchem
Family:  Enzyme
Novelty:  0.0054436
Score:  0.945
Data Source:  STRINGDB
HIBADH
Tbio
Family:  Enzyme
Novelty:  0.03861647
Score:  0.937
Data Source:  STRINGDB
CNDP2
Tbio
Family:  Enzyme
Novelty:  0.00157228
Score:  0.933
Data Source:  STRINGDB
ALDH6A1
Tbio
Family:  Enzyme
Novelty:  0.03785268
Score:  0.932
Data Source:  STRINGDB
GLYCTK
Tbio
Family:  Kinase
Novelty:  0.06383854
Score:  0.931
Data Source:  STRINGDB
AGXT2
Tbio
Family:  Enzyme
Novelty:  0.02018289
Score:  0.927
Data Source:  STRINGDB
ACSF3
Tbio
Family:  Enzyme
Novelty:  0.04255285
Score:  0.926
Data Source:  STRINGDB
Publication Statistics
PubMed Score  55.31

PubMed score by year
PubTator Score  20.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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