ALDH9A1
4-trimethylaminobutyraldehyde dehydrogenase
Protein Summary
Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction. This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits. [provided by RefSeq, Jul 2008]
- ENST00000354775
- ENSP00000346827
- ENSG00000143149
- ENST00000538148
- ENSP00000440026
- ALDH4
- ALDH7
- ALDH9
- E3
- ALDH4
- ALDH7
- ALDH9
- TMABADH
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.99 | ||
disease perturbation | 0.96 | ||
kinase perturbation | 0.91 | ||
protein domain | 0.85 | ||
molecular function | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 60.9 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 226 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 60.9 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 226 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0