Tbio DNASE1L1 Deoxyribonuclease-1-like 1

Protein Summary

Description

This gene encodes a deoxyribonuclease protein that shows high sequence similarity to DNase I. The encoded protein is localized to the endoplasmic reticulum and modified by N-linked glycosylation. Alternate transcriptional splice variants encoding the same protein have been observed. [provided by RefSeq, Jan 2015]

Uniprot Accession IDs

• P49184
• D3DWW7
• Q5HY41

Gene Name

• DNASE1L1

Ensembl ID

• ENST00000014935
• ENSP00000014935
• ENSG00000013563
• ENST00000309585
• ENSP00000309168
• ENST00000369807
• ENSP00000358822
• ENST00000369808
• ENSP00000358823
• ENST00000369809
• ENSP00000358824
• ENST00000393638
• ENSP00000377255

Symbol

• DNAS1L1
• DNL1L
• XIB
• G4.8
• DNL1L
• DNASEX
• DNAS1L1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.84
kinase perturbation	0.81
tissue sample	0.66
tissue	0.65
disease perturbation	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.34   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 157   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.34   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0