Tchem NPY2R Neuropeptide Y receptor type 2

Protein Summary

Description

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.

Uniprot Accession IDs

• P49146
• Q13281
• Q13457
• Q4W5G7
• Q6AZZ6
• Q9UE67
• NPY2-R

Gene Name

• NPY2R

Ensembl ID

• ENST00000329476
• ENSP00000332591
• ENSG00000185149
• ENST00000506608
• ENSP00000426366

Symbol

• NPY2-R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.94
phenotype	0.87
ligand (chemical)	0.82
kinase perturbation	0.71
cell type or tissue	0.7

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Neuropeptide Y Receptor / Neuropeptide Y Receptor Type 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.26   (req: < 5)

Gene RIFs: 52   (req: <= 3)

Antibodies: 271   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.26   (req: >= 5)

Gene RIFs: 52   (req: > 3)

Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 293

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0