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Tchem
MAPKAPK2
MAP kinase-activated protein kinase 2

Protein Summary
Description
Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities (PubMed:16278218). Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to the dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone acti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294981
  • ENSP00000294981
  • ENSG00000162889
  • ENST00000367103
  • ENSP00000356070

Symbol
  • MK2
  • MK-2
  • MAPKAP-K2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
biological process
0.98
kinase perturbation
0.98
hub protein
0.97
protein domain
0.85


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.55   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 855   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.55   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 855   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 190
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (190)
1 – 10 of 190
CHEMBL1092754
chemical structure image
compound 33 [PMID: 19364658]
chemical structure image
CHEMBL461139
chemical structure image
CHEMBL225519
chemical structure image
CHEMBL226403
chemical structure image
CHEMBL1089865
chemical structure image
CHEMBL562754,CHEMBL557318
chemical structure image
CHEMBL553397
chemical structure image
CHEMBL1801373
chemical structure image
CHEMBL1801374
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
1
1
0
1.2
93.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
0
1.2
93.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase-activated protein kinase 2
VGNC:8074
744091
Macaque
mitogen-activated protein kinase-activated protein kinase 2
695044
Mouse
MGI:109298
17164
Rat
RGD:631362
289014
Dog
mitogen-activated protein kinase-activated protein kinase 2
VGNC:43006
490263
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase-activated protein kinase 2
Macaque
mitogen-activated protein kinase-activated protein kinase 2
Mouse
Rat
Dog
mitogen-activated protein kinase-activated protein kinase 2
Protein Structure (25 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49137-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 25
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (101)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 50
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Reactome
CREB phosphorylation
Reactome
Cellular Senescence
Reactome
Cellular response to heat stress
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
CREB phosphorylation
Cellular Senescence
Cellular response to heat stress
Gene Ontology Terms (34)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (114)
1 – 10 of 114
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
p_int: 0.999999994
p_ni: 6e-9
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
HSPB1
Tchem
Novelty: 0.00081373
Score: 0.993
Data Source: STRINGDB
MAPK11
Tchem
Family: Kinase
Novelty: 0.00545217
Score: 0.992
Data Source: Reactome,STRINGDB
ZFP36
Tbio
Novelty: 0.00349514
Score: 0.978
Data Source: Reactome,STRINGDB
CREB1
Tbio
Family: TF
Novelty: 0.00018059
Score: 0.976
Data Source: Reactome,STRINGDB
MAPK13
Tchem
Family: Kinase
Novelty: 0.01071621
Score: 0.97
Data Source: STRINGDB
TSC2
Tbio
Novelty: 0.00067416
Score: 0.969
Data Source: STRINGDB
MAPK12
Tchem
Family: Kinase
Novelty: 0.00835017
Score: 0.968
Data Source: STRINGDB
LSP1
Tbio
Novelty: 0.00889927
Score: 0.965
Data Source: STRINGDB
YWHAZ
Tbio
Novelty: 0.00210582
Score: 0.962
Data Source: STRINGDB
Publication Statistics
PubMed Score  201.55

PubMed score by year
PubTator Score  304.18

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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