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Tchem
NR2C2
Nuclear receptor subfamily 2 group C member 2

Protein Summary
Description
Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. This gene encodes a protein that belongs to the n ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323373
  • ENSP00000320447
  • ENSG00000177463
  • ENST00000393102
  • ENSP00000376814
  • ENST00000406272
  • ENSP00000384463
  • ENST00000425241
  • ENSP00000388387
  • ENST00000617312
  • ENSP00000483059

Symbol
  • TAK1
  • TR4
  • TR4
  • TAK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
kinase perturbation
0.84
histone modification site profile
0.81
biological process
0.74
protein domain
0.73


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.47   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 448   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.47   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 448   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
tretinoin
chemical structure image
retinol
chemical structure image
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 2 group C member 2
VGNC:12095
460199
Macaque
nuclear receptor subfamily 2 group C member 2
703135
Mouse
MGI:1352466
22026
Rat
RGD:3201
50659
Dog
nuclear receptor subfamily 2 group C member 2
VGNC:43947
484641
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 2 group C member 2
Macaque
nuclear receptor subfamily 2 group C member 2
Mouse
Rat
Dog
nuclear receptor subfamily 2 group C member 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49116-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (123)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Nuclear Receptor transcription pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Nuclear Receptor transcription pathway
RNA Polymerase II Transcription
Gene Ontology Terms (19)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (66)
1 – 10 of 66
CD70
Tbio
Novelty: 0.00420393
p_int: 0.999825023
p_ni: 0.000001318
p_wrong: 0.000173659
Score: 0.177
Data Source: BioPlex,STRINGDB
UBB
Tbio
Novelty: 0.00661254
p_int: 0.752744482
p_ni: 0.247255518
Score: 0.157
Data Source: BioPlex,STRINGDB
TAB1
Tchem
Family: Kinase
Novelty: 0.00721424
Score: 0.966
Data Source: STRINGDB
TGFB2
Tbio
Novelty: 0.00050804
Score: 0.929
Data Source: STRINGDB
WDR34
Tbio
Novelty: 0.05515847
Score: 0.923
Data Source: STRINGDB
MAP3K7
Tchem
Family: Kinase
Novelty: 0.00540177
Score: 0.92
Data Source: STRINGDB
TGFBR2
Tchem
Family: Kinase
Novelty: 0.00085381
Score: 0.918
Data Source: STRINGDB
MED1
Tbio
Family: Enzyme
Novelty: 0.00852082
Score: 0.917
Data Source: STRINGDB
MAP2K6
Tchem
Family: Kinase
Novelty: 0.00569655
Score: 0.907
Data Source: STRINGDB
TGFBR1
Tchem
Family: Kinase
Novelty: 0.00081645
Score: 0.904
Data Source: STRINGDB
Publication Statistics
PubMed Score  284.47

PubMed score by year
PubTator Score  70.24

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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