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Tchem
NR2C2
Nuclear receptor subfamily 2 group C member 2

Protein Summary
Description
Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. This gene encodes a protein that belongs to the n ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323373
  • ENSP00000320447
  • ENSG00000177463
  • ENST00000393102
  • ENSP00000376814
  • ENST00000406272
  • ENSP00000384463
  • ENST00000425241
  • ENSP00000388387
  • ENST00000617312
  • ENSP00000483059

Symbol
  • TAK1
  • TR4
  • TR4
  • TAK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
kinase perturbation
0.84
histone modification site profile
0.81
biological process
0.74
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 297.91   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 448   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 297.91   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 448   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (66)
CD70
Tbio
Novelty:  0.00420393
p_int:  0.999825023
p_ni:  0.000001318
p_wrong:  0.000173659
Score:  0.177
Data Source:  BioPlex,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.752744482
p_ni:  0.247255518
Score:  0.157
Data Source:  BioPlex,STRINGDB
TAB1
Tchem
Family:  Kinase
Novelty:  0.00721424
Score:  0.966
Data Source:  STRINGDB
TGFB2
Tbio
Novelty:  0.00050804
Score:  0.929
Data Source:  STRINGDB
WDR34
Tbio
Novelty:  0.05515847
Score:  0.923
Data Source:  STRINGDB
MAP3K7
Tchem
Family:  Kinase
Novelty:  0.00540177
Score:  0.92
Data Source:  STRINGDB
TGFBR2
Tchem
Family:  Kinase
Novelty:  0.00085381
Score:  0.918
Data Source:  STRINGDB
MED1
Tbio
Family:  Enzyme
Novelty:  0.00852082
Score:  0.917
Data Source:  STRINGDB
MAP2K6
Tchem
Family:  Kinase
Novelty:  0.00569655
Score:  0.907
Data Source:  STRINGDB
TGFBR1
Tchem
Family:  Kinase
Novelty:  0.00081645
Score:  0.904
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (123)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Nuclear Receptor transcription pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Nuclear Receptor transcription pathway
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
6
4
1.1
87.8
hemoglobin measurement
2
2
2
84.1
hematocrit
2
2
2
80.3
diastolic blood pressure
3
3
4
78.4
2
3
3
73.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
87.8
hemoglobin measurement
2
84.1
hematocrit
2
80.3
diastolic blood pressure
4
78.4
3
73.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 2 group C member 2
VGNC:12095
460199
Macaque
nuclear receptor subfamily 2 group C member 2
703135
Mouse
MGI:1352466
22026
Rat
RGD:3201
50659
Dog
nuclear receptor subfamily 2 group C member 2
VGNC:43947
484641
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 2 group C member 2
Macaque
nuclear receptor subfamily 2 group C member 2
Mouse
Rat
Dog
nuclear receptor subfamily 2 group C member 2
Publication Statistics
PubMed Score 297.91
PubMed score by year
PubTator Score 70.24
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title