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Tchem
HCAR3
Hydroxycarboxylic acid receptor 3

Protein Summary
Description
Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000528880
  • ENSP00000436714
  • ENSG00000255398

Symbol
  • GPR109B
  • HCA3
  • HM74B
  • NIACR2
  • HCA3
  • HM74
  • PUMAG
  • Puma-g
  • GPR109B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
gene perturbation
0.7
small molecule perturbation
0.64
tissue
0.63
PubMedID
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.39   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.39   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (10)
1 – 10 of 10
Pathways (9)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Hydroxycarboxylic acid-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Hydroxycarboxylic acid-binding receptors
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (230)
1 – 10 of 230
HCAR2
Tclin
Family: GPCR
Novelty: 0.00768366
Score: 0.971
Data Source: STRINGDB
CCL4
Tbio
Novelty: 0.00091965
Score: 0.927
Data Source: STRINGDB
NPB
Tdark
Novelty: 0.00254878
Score: 0.925
Data Source: STRINGDB
CXCR1
Tchem
Family: GPCR
Novelty: 0.00285279
Score: 0.925
Data Source: STRINGDB
FPR2
Tchem
Family: GPCR
Novelty: 0.00286277
Score: 0.923
Data Source: STRINGDB
BDKRB2
Tclin
Family: GPCR
Novelty: 0.00504032
Score: 0.92
Data Source: STRINGDB
CCR1
Tchem
Family: GPCR
Novelty: 0.00293956
Score: 0.92
Data Source: STRINGDB
SUCNR1
Tchem
Family: GPCR
Novelty: 0.01763364
Score: 0.92
Data Source: STRINGDB
FPR1
Tchem
Family: GPCR
Novelty: 0.00150161
Score: 0.918
Data Source: STRINGDB
GNGT2
Tbio
Novelty: 0.05824157
Score: 0.917
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.39

PubMed score by year
PubTator Score  68.25

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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