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Tchem
HCAR3
Hydroxycarboxylic acid receptor 3

Protein Summary
Description
Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000528880
  • ENSP00000436714
  • ENSG00000255398

Symbol
  • GPR109B
  • HCA3
  • HM74B
  • NIACR2
  • HCA3
  • HM74
  • PUMAG
  • Puma-g
  • GPR109B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
gene perturbation
0.7
small molecule perturbation
0.64
tissue
0.63
PubMedID
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.41   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.41   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 21
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0