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Tchem
HCAR3
Hydroxycarboxylic acid receptor 3

Protein Summary
Description
Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000528880
  • ENSP00000436714
  • ENSG00000255398

Symbol
  • GPR109B
  • HCA3
  • HM74B
  • NIACR2
  • HCA3
  • HM74
  • PUMAG
  • Puma-g
  • GPR109B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
gene perturbation
0.7
small molecule perturbation
0.64
tissue
0.63
PubMedID
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.62   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.62   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (10)
1 – 10 of 10
2-hydroxyoctanoic acid
chemical structure image
3-hydroxyoctanoic acid
chemical structure image
compound 6o [PMID: 19524438]
chemical structure image
D-kynurenine
chemical structure image
D-phenylalanine
chemical structure image
D-tryptophan
chemical structure image
IBC 293
chemical structure image
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
77
high density lipoprotein cholesterol measurement
2
2
2
67.7
triglyceride measurement
2
1
2
11.2
sleep duration
1
1
1
4.2
reticulocyte measurement
1
1
1
1.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
77
high density lipoprotein cholesterol measurement
2
67.7
triglyceride measurement
2
11.2
sleep duration
1
4.2
reticulocyte measurement
1
1.8
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hydroxycarboxylic acid receptor 3
VGNC:13105
452411
Mouse
MGI:1933383
80885
Rat
RGD:727952
353250
Opossum
hydroxycarboxylic acid receptor 2
100022273
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hydroxycarboxylic acid receptor 3
Mouse
Rat
Opossum
hydroxycarboxylic acid receptor 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P49019-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Hydroxycarboxylic acid-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Hydroxycarboxylic acid-binding receptors
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (230)
1 – 10 of 230
HCAR2
Tclin
Family: GPCR
Novelty: 0.0054199
Score: 0.971
Data Source: STRINGDB
CCL4
Tbio
Novelty: 0.00069278
Score: 0.927
Data Source: STRINGDB
NPB
Tdark
Novelty: 0.00936692
Score: 0.925
Data Source: STRINGDB
CXCR1
Tchem
Family: GPCR
Novelty: 0.00224501
Score: 0.925
Data Source: STRINGDB
FPR2
Tchem
Family: GPCR
Novelty: 0.00228744
Score: 0.923
Data Source: STRINGDB
BDKRB2
Tclin
Family: GPCR
Novelty: 0.00335227
Score: 0.92
Data Source: STRINGDB
CCR1
Tchem
Family: GPCR
Novelty: 0.00218065
Score: 0.92
Data Source: STRINGDB
SUCNR1
Tchem
Family: GPCR
Novelty: 0.01482891
Score: 0.92
Data Source: STRINGDB
FPR1
Tchem
Family: GPCR
Novelty: 0.00256884
Score: 0.918
Data Source: STRINGDB
GNGT2
Tbio
Novelty: 0.0468008
Score: 0.917
Data Source: STRINGDB
Publication Statistics
PubMed Score  24.62

PubMed score by year
PubTator Score  68.25

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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