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Tbio
MARCKSL1
MARCKS-related protein

Protein Summary
Description
Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity). This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on the long arm of chromosomes 6 and 10. [provided by RefSeq, Jun 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329421
  • ENSP00000362638
  • ENSG00000175130

Symbol
  • MLP
  • MRP
  • F52
  • MLP
  • MRP
  • MLP1
  • MACMARCKS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
virus perturbation
0.92
gene perturbation
0.91
drug perturbation
0.87
interacting protein
0.79


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.41   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.41   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MARCKS like 1
VGNC:11533
745609
Macaque
MARCKS like 1
100428619
Mouse
MGI:97143
17357
Rat
RGD:621197
81520
Dog
MARCKS like 1
VGNC:43022
612998
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MARCKS like 1
Macaque
MARCKS like 1
Mouse
Rat
Dog
MARCKS like 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P49006-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (47)
1 – 10 of 47
SNX21
Tdark
Novelty: 0.32916633
p_int: 0.999992422
p_ni: 0.000007578
Score: 0.153
Data Source: BioPlex,STRINGDB
RBP4
Tchem
Novelty: 0.00168442
p_int: 0.999981238
p_ni: 0.000018762
Score: 0.165
Data Source: BioPlex,STRINGDB
NMT2
Tchem
Family: Enzyme
Novelty: 0.04826835
p_int: 0.999898742
p_ni: 0.000101248
p_wrong: 1e-8
Data Source: BioPlex
RMI1
Tbio
Novelty: 0.01222442
p_int: 0.999792816
p_ni: 0.000032196
p_wrong: 0.000174988
Score: 0.71
Data Source: BioPlex,STRINGDB
BCCIP
Tbio
Novelty: 0.02710491
p_int: 0.998665305
p_ni: 0.001334695
Score: 0.188
Data Source: BioPlex,STRINGDB
NMT1
Tchem
Family: Enzyme
Novelty: 0.00343834
p_int: 0.997723288
p_ni: 0.002276712
Data Source: BioPlex
PPP4R3A
Tbio
Family: Enzyme
Novelty: 0.04234592
p_int: 0.996862954
p_ni: 0.003137046
Score: 0.293
Data Source: BioPlex,STRINGDB
TOP3A
Tbio
Family: Enzyme
Novelty: 0.0055546
p_int: 0.995861671
p_ni: 0.004137754
p_wrong: 5.74e-7
Score: 0.213
Data Source: BioPlex,STRINGDB
SCRN2
Tdark
Family: Enzyme
Novelty: 1.63547022
p_int: 0.952886092
p_ni: 0.047113903
p_wrong: 5e-9
Score: 0.165
Data Source: BioPlex,STRINGDB
ATP6V1D
Tbio
Family: Enzyme
Novelty: 0.02298626
p_int: 0.915121373
p_ni: 0.084865804
p_wrong: 0.000012823
Score: 0.513
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  73.41

PubMed score by year
PubTator Score  106.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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