You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
POLD2
DNA polymerase delta subunit 2

Protein Summary
Description
As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:12403614, PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000406581
  • ENSP00000386105
  • ENSG00000106628
  • ENST00000452185
  • ENSP00000395231
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
histone modification site profile
0.82
disease perturbation
0.74
protein complex
0.7
cell type or tissue
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.35   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.35   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (50)
Base Excision Repair (R-HSA-73884)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 41
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Base Excision Repair
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Chromosome Maintenance
Reactome
DNA Damage Bypass
Name
Explore in Pharos
Explore in Source
Base Excision Repair
Cell Cycle
Cell Cycle, Mitotic
Chromosome Maintenance
DNA Damage Bypass
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (243)
1 – 10 of 243
REV3L
Tbio
Family: Enzyme
Novelty: 0.00411916
p_int: 0.999999995
p_ni: 5e-9
Score: 0.965
Data Source: BioPlex,STRINGDB
POLD4
Tdark
Family: Enzyme
Novelty: 0.21865352
p_int: 0.999998777
p_ni: 1e-9
p_wrong: 0.000001222
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
POLD1
Tclin
Family: Enzyme
Novelty: 0.00508209
p_int: 0.999749253
p_ni: 0.000250747
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
AMZ1
Tdark
Family: Enzyme
Novelty: 0.246305
p_int: 0.999581175
p_ni: 0.000418825
Score: 0.169
Data Source: BioPlex,STRINGDB
SPANXN4
Tdark
Novelty: 1.91062423
p_int: 0.989405637
p_ni: 0.010594363
Data Source: BioPlex
POLD3
Tbio
Family: Enzyme
Novelty: 0.02646621
p_int: 0.986944038
p_ni: 0.013055962
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
PPP5C
Tbio
Family: Enzyme
Novelty: 0.01990823
p_int: 0.960531824
p_ni: 0.039468172
p_wrong: 4e-9
Score: 0.238
Data Source: BioPlex,STRINGDB
DKKL1
Tbio
Novelty: 0.00544618
p_int: 0.954921386
p_ni: 0.045078547
p_wrong: 6.7e-8
Data Source: BioPlex
ERP44
Tbio
Novelty: 0.02352693
p_int: 0.916999305
p_ni: 0.083000695
Score: 0.269
Data Source: BioPlex,STRINGDB
PHF8
Tchem
Family: Epigenetic
Novelty: 0.01946151
p_int: 0.908496825
p_ni: 0.091502964
p_wrong: 2.11e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  16.35

PubMed score by year
PubTator Score  8.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer