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Tbio
TRPC1
Short transient receptor potential channel 1

Protein Summary
Description
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273482
  • ENSP00000273482
  • ENSG00000144935
  • ENST00000476941
  • ENSP00000419313
  • ENST00000612385
  • ENSP00000481537

Symbol
  • TRP1
  • TRP1
  • HTRP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
molecular function
0.9
histone modification site profile
0.86
biological term
0.84
biological process
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 468.15   (req: < 5)
Gene RIFs: 132   (req: <= 3)
Antibodies: 229   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 468.15   (req: >= 5)
Gene RIFs: 132   (req: > 3)
Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (113)
STIM1
Tbio
Novelty:  0.00116516
Score:  0.996
Data Source:  Reactome,STRINGDB
ITPR3
Tchem
Family:  IC
Novelty:  0.00154917
Score:  0.987
Data Source:  STRINGDB
ITPR1
Tchem
Family:  IC
Novelty:  0.00111834
Score:  0.979
Data Source:  STRINGDB
ITPR2
Tbio
Family:  IC
Novelty:  0.00619813
Score:  0.968
Data Source:  STRINGDB
TRPC4
Tchem
Family:  IC
Novelty:  0.00339889
Score:  0.951
Data Source:  Reactome,STRINGDB
TRPC5
Tchem
Family:  IC
Novelty:  0.00406517
Score:  0.948
Data Source:  Reactome,STRINGDB
TRPC3
Tchem
Family:  IC
Novelty:  0.00268752
Score:  0.947
Data Source:  Reactome,STRINGDB
TRPC6
Tchem
Family:  IC
Novelty:  0.00118598
Score:  0.941
Data Source:  Reactome,STRINGDB
PLCG1
Tchem
Family:  Enzyme
Novelty:  0.00110273
Score:  0.926
Data Source:  STRINGDB
TRPV4
Tchem
Family:  IC
Novelty:  0.00111193
Score:  0.92
Data Source:  STRINGDB
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
1 – 5 of 7
GRIN2B
Tclin
Family:  Ion Channel
KEGG Distance:  6
Common Pathways:  1
GRIN3B
Tclin
Family:  Ion Channel
KEGG Distance:  6
Common Pathways:  1
GRIN3A
Tclin
Family:  Ion Channel
KEGG Distance:  6
Common Pathways:  1
GRIN2C
Tclin
Family:  Ion Channel
KEGG Distance:  6
Common Pathways:  1
GRIN2A
Tclin
Family:  Ion Channel
KEGG Distance:  6
Common Pathways:  1
Pathways (56)
Adaptive Immune System (R-HSA-1280218)

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Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome
Axon guidance
Reactome
Cardiac conduction
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Axon guidance
Cardiac conduction
Developmental Biology
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
45.5
creatinine measurement
1
1
1
39.6
glomerular filtration rate
1
1
1
33.1
total cholesterol measurement
1
1
1
7.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
45.5
creatinine measurement
1
39.6
glomerular filtration rate
1
33.1
total cholesterol measurement
1
7.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily C member 1
VGNC:8016
460747
Macaque
transient receptor potential cation channel subfamily C member 1
714334
Mouse
MGI:109528
22063
Rat
RGD:619783
89821
Dog
transient receptor potential cation channel subfamily C member 1
VGNC:47866
485698
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily C member 1
Macaque
transient receptor potential cation channel subfamily C member 1
Mouse
Rat
Dog
transient receptor potential cation channel subfamily C member 1
Publication Statistics
PubMed Score 468.15
PubMed score by year
PubTator Score 282.65
PubTator score by year
Patents
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Related Publications
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PMID
Year
Title