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Tbio
ADGRE5
CD97 antigen

Protein Summary
Description
Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity). This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242786
  • ENSP00000242786
  • ENSG00000123146
  • ENST00000357355
  • ENSP00000349918
  • ENST00000358600
  • ENSP00000351413

Symbol
  • CD97
  • TM7LN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
kinase perturbation
0.97
PubMedID
0.97
virus perturbation
0.9
transcription factor binding site profile
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.84   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 813   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.84   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 813   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
2
4
89.8
myeloid white cell count
1
1
1
71.2
lymphocyte count
1
1
1
70.5
leukocyte count
1
1
1
67.7
reticulocyte count
2
1
2
65.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
89.8
myeloid white cell count
1
71.2
lymphocyte count
1
70.5
leukocyte count
1
67.7
reticulocyte count
2
65.9
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor E5
VGNC:6608
455780
Mouse
MGI:1347095
26364
Rat
RGD:1305595
361383
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor E5
Mouse
Rat
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P48960-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
GPCRs, Class B Secretin-like
WikiPathways
GPCRs, Class B Secretin-like
WikiPathways
Endochondral Ossification
WikiPathways
Vitamin D Receptor Pathway
Name
Explore in Pharos
Explore in Source
GPCRs, Class B Secretin-like
GPCRs, Class B Secretin-like
Endochondral Ossification
Vitamin D Receptor Pathway
Protein-Protein Interactions (75)
1 – 10 of 75
TNFSF18
Tbio
Novelty:  0.01423949
p_int:  0.999999704
p_ni:  2.96e-7
Data Source:  BioPlex
TPST1
Tbio
Family:  Enzyme
Novelty:  0.03915379
p_int:  0.999996291
p_ni:  0.000003363
p_wrong:  3.46e-7
Data Source:  BioPlex
ADGRE2
Tbio
Family:  GPCR
Novelty:  0.02097264
p_int:  0.999995548
p_wrong:  0.000004452
Score:  0.238
Data Source:  BioPlex,STRINGDB
NNT
Tbio
Family:  Enzyme
Novelty:  0.00269343
p_int:  0.999989761
p_ni:  0.000010239
Score:  0.181
Data Source:  BioPlex,STRINGDB
ADARB1
Tbio
Family:  Enzyme
Novelty:  0.00586819
p_int:  0.999960106
p_ni:  0.000039872
p_wrong:  2.2e-8
Score:  0.253
Data Source:  BioPlex,STRINGDB
ZDHHC21
Tbio
Family:  Enzyme
Novelty:  0.11768266
p_int:  0.999822115
p_ni:  0.000174413
p_wrong:  0.000003472
Data Source:  BioPlex
TMEM120B
Tdark
Novelty:  1.46242586
p_int:  0.996863417
p_ni:  0.003086331
p_wrong:  0.000050251
Score:  0.216
Data Source:  BioPlex,STRINGDB
MTCH2
Tbio
Novelty:  0.01794294
p_int:  0.995849702
p_ni:  0.004143709
p_wrong:  0.000006589
Data Source:  BioPlex
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
p_int:  0.994778908
p_ni:  0.005221091
Score:  0.441
Data Source:  BioPlex,STRINGDB
GLT8D1
Tbio
Family:  Enzyme
Novelty:  0.14670166
p_int:  0.993601851
p_ni:  0.006398149
Data Source:  BioPlex
Publication Statistics
PubMed Score  110.84

PubMed score by year
PubTator Score  64.04

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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