Tbio ADGRE5 CD97 antigen

Protein Summary

Description

Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity). This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011]

Uniprot Accession IDs

• P48960
• A8K7Z4
• B2RBJ9
• O00718
• O76101
• Q8NG72
• Q8TBQ7

Gene Name

• ADGRE5

Ensembl ID

• ENST00000242786
• ENSP00000242786
• ENSG00000123146
• ENST00000357355
• ENSP00000349918
• ENST00000358600
• ENSP00000351413

Symbol

• CD97
• TM7LN1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
kinase perturbation	0.97
PubMedID	0.97
virus perturbation	0.9
transcription factor binding site profile	0.8

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Cd97 Antigen

Protein / Defense/immunity Protein / Antibacterial Response Protein / Cd97 Antigen

Protein / ... / Protease / Cd97 Antigen

DTO Classes

Protein / G-protein Coupled Receptor / Adhesion Class / Cd97 Antigen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.36   (req: < 5)

Gene RIFs: 59   (req: <= 3)

Antibodies: 813   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.36   (req: >= 5)

Gene RIFs: 59   (req: > 3)

Antibodies: 813   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0