Tbio TNNI2 Troponin I, fast skeletal muscle

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Troponin I, Fast Skeletal Muscle

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Troponin I, Fast Skeletal Muscle

Protein Summary

Description

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• P48788
• A6NIV8
• A6NJU5

Gene Name

• TNNI2

Ensembl ID

• ENST00000252898
• ENSP00000252898
• ENSG00000130598
• ENST00000381905
• ENSP00000371330
• ENST00000381906
• ENSP00000371331
• ENST00000381911
• ENSP00000371336

Symbol

• DA2B
• FSSV
• fsTnI
• AMCD2B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.59
disease perturbation	0.56
cellular component	0.53
tissue sample	0.53
transcription factor	0.5

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.38   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 403   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.38   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 403   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte count	EFO_0005091	2	1	2		36.5
monocyte percentage of leukocytes	EFO_0007989	2	1	2		15.6
ulcerative colitis	EFO_0000729	2	1	0	1.1	13.5
inflammatory bowel disease	EFO_0003767	2	1	0	1.1	6.8
bladder carcinoma	EFO_0000292	1	1	0	1.1	4

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte count	EFO_0005091	2		36.5
monocyte percentage of leukocytes	EFO_0007989	2		15.6
ulcerative colitis	EFO_0000729	0	1.1	13.5
inflammatory bowel disease	EFO_0003767	0	1.1	6.8
bladder carcinoma	EFO_0000292	0	1.1	4

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Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	troponin I2, fast skeletal type	VGNC:7695	466317
Macaque	troponin I2, fast skeletal type		721041
Mouse	troponin I, skeletal, fast 2	MGI:105070	21953
Rat	troponin I2, fast skeletal type	RGD:62050	29389
Dog	troponin I2, fast skeletal type	VGNC:52055	475995

Species	Name	OMA	EggNOG	Inparanoid
Chimp	troponin I2, fast skeletal type
Macaque	troponin I2, fast skeletal type
Mouse	troponin I, skeletal, fast 2
Rat	troponin I2, fast skeletal type
Dog	troponin I2, fast skeletal type

Protein Structure (1 Structure, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P48788-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (3)

Reactome (2)

WikiPathways (1)

Muscle contraction (R-HSA-397014)

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Find Similar Targets

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Muscle contraction	202 targets	R-HSA-397014
Reactome	Striated Muscle Contraction	34 targets	R-HSA-390522

Name	Explore in Pharos	Explore in Source
Muscle contraction	202 targets	R-HSA-397014
Striated Muscle Contraction	34 targets	R-HSA-390522

Gene Ontology Terms (11)

Functions (2)

Components (3)

Processes (6)

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
troponin T binding	Inferred from Physical Interaction (IPI)	UniProtKB
actin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (114)

Explore Interacting Targets

1 – 10 of 114

• See Interactions on String-DB

NUCB2

Tbio

Novelty: 0.00831106

p_int: 0.999999991

p_ni: 9e-9

Score: 0.391

Data Source: BioPlex,STRINGDB

RFTN2

Tdark

Novelty: 0.99330616

p_int: 0.999802384

p_ni: 0.00019509

p_wrong: 0.000002525

Score: 0.214

Data Source: BioPlex,STRINGDB

KLHL21

Tbio

Novelty: 0.20694121

p_int: 0.999760359

p_ni: 0.000238169

p_wrong: 0.000001472

Score: 0.245

Data Source: BioPlex,STRINGDB

MECOM

Tbio

Family: TF; Epigenetic

Novelty: 0.00500501

p_int: 0.999711041

p_ni: 0.000010915

p_wrong: 0.000278044

Data Source: BioPlex

TLE4

Tbio

Novelty: 0.02094922

p_int: 0.995455479

p_ni: 0.004544521

Score: 0.188

Data Source: BioPlex,STRINGDB

TLE1

Tbio

Novelty: 0.00594261

p_int: 0.895772821

p_ni: 0.104227179

Score: 0.239

Data Source: BioPlex,STRINGDB

SIRT1

Tchem

Family: Epigenetic

Novelty: 0.00022265

p_int: 0.764885791

p_ni: 0.235114209

Score: 0.184

Data Source: BioPlex,STRINGDB

TNNC2

Tbio

Novelty: 0.07759506

Score: 0.999

Data Source: Reactome,STRINGDB

TNNC1

Tclin

Novelty: 0.03535727

Score: 0.999

Data Source: Reactome,STRINGDB

TNNT3

Tbio

Novelty: 0.0212335

Score: 0.999

Data Source: Reactome,STRINGDB

Publication Statistics

PubMed Score  34.38

PubMed score by year

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PubTator Score  18.51

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Acetylation
Actin-binding
Alternative splicing
Complete proteome
Disease mutation
Muscle protein
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

bladder carcinoma
granulocyte percentage of myeloid white cells
inflammatory bowel disease
monocyte count
monocyte percentage of leukocytes
ulcerative colitis

MGI Phenotype Find Similar Targets

adipose tissue phenotype
cardiovascular system phenotype
cellular phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
integument phenotype
limbs/digits/tail phenotype
mortality/aging
skeleton phenotype