Tbio TNNI2 Troponin I, fast skeletal muscle

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Troponin I, Fast Skeletal Muscle

Protein Summary

Description

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• P48788
• A6NIV8
• A6NJU5

Gene Name

• TNNI2

Ensembl ID

• ENST00000252898
• ENSP00000252898
• ENSG00000130598
• ENST00000381905
• ENSP00000371330
• ENST00000381906
• ENSP00000371331
• ENST00000381911
• ENSP00000371336

Symbol

• DA2B
• FSSV
• fsTnI
• AMCD2B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.59
disease perturbation	0.56
cellular component	0.53
tissue sample	0.53
transcription factor	0.5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.6   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 403   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.6   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 403   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (3)

Reactome (2)

WikiPathways (1)

Muscle contraction (R-HSA-397014)

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Items per page:

5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Muscle contraction	202 targets	R-HSA-397014
Reactome	Striated Muscle Contraction	34 targets	R-HSA-390522

Name	Explore in Pharos	Explore in Source
Muscle contraction	202 targets	R-HSA-397014
Striated Muscle Contraction	34 targets	R-HSA-390522

Gene Ontology Terms (11)

Functions (2)

Components (3)

Processes (6)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
troponin T binding	Inferred from Physical Interaction (IPI)	UniProtKB
actin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (114)

Explore Interacting Targets

1 – 10 of 114

• See Interactions on String-DB

NUCB2

Tbio

Novelty: 0.00828843

p_int: 0.999999991

p_ni: 9e-9

Score: 0.391

Data Source: BioPlex,STRINGDB

RFTN2

Tdark

Novelty: 1.69230769

p_int: 0.999802384

p_ni: 0.00019509

p_wrong: 0.000002525

Score: 0.214

Data Source: BioPlex,STRINGDB

KLHL21

Tbio

Novelty: 0.51282051

p_int: 0.999760359

p_ni: 0.000238169

p_wrong: 0.000001472

Score: 0.245

Data Source: BioPlex,STRINGDB

MECOM

Tbio

Family: TF; Epigenetic

Novelty: 0.00805252

p_int: 0.999711041

p_ni: 0.000010915

p_wrong: 0.000278044

Data Source: BioPlex

TLE4

Tbio

Novelty: 0.02737837

p_int: 0.995455479

p_ni: 0.004544521

Score: 0.188

Data Source: BioPlex,STRINGDB

TLE1

Tbio

Novelty: 0.00854022

p_int: 0.895772821

p_ni: 0.104227179

Score: 0.239

Data Source: BioPlex,STRINGDB

SIRT1

Tchem

Family: Epigenetic

Novelty: 0.00025951

p_int: 0.764885791

p_ni: 0.235114209

Score: 0.184

Data Source: BioPlex,STRINGDB

TNNC2

Tbio

Novelty: 0.11856592

Score: 0.999

Data Source: Reactome,STRINGDB

TNNC1

Tclin

Novelty: 0.06813757

Score: 0.999

Data Source: Reactome,STRINGDB

TNNT3

Tbio

Novelty: 0.0268478

Score: 0.999

Data Source: Reactome,STRINGDB

Publication Statistics

PubMed Score  23.60

PubMed score by year

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PubTator Score  18.51

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MGDEEKRNRAITARRQHLKSVMLQIAATELEKEESRREAEKQNYLAEHCPPLHIPGSMSEVQELCKQLHA

1-70

KIDAAEEEKYDMEVRVQKTSKELEDMNQKLFDLRGKFKRPPLRRVRMSADAMLKALLGSKHKVCMDLRAN

70-140

LKQVKKEDTEKERDLRDVGDWRKNIEEKSGMEGRKKMFESES

140-182

MGDEEKRNRAITARRQHLKSVMLQIAATELEKEESRREAEKQNYLAEHCPPLHIPGSMSEVQELCKQLHAKIDAAEEEKYDMEVRVQKTSKELEDMNQKLFDLRGKFKRPPLRRVRMSADAMLKALLGSKHKVCMDLRANLKQVKKEDTEKERDLRDVGDWRKNIEEKSGMEGRKKMFESES

Find similar targets by:

Uniprot Keyword

3D-structure
Acetylation
Actin-binding
Alternative splicing
Complete proteome
Disease mutation
Muscle protein
Phosphoprotein
Reference proteome