TDO2
Tryptophan 2,3-dioxygenase
Protein Summary
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]
- ENST00000536354
- ENSP00000444788
- ENSG00000151790
- ENST00000573403
- ENSP00000460086
- ENSG00000262635
- TDO
- TO
- TDO
- TPH2
- TRPO
- HYPTRP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.8 | ||
molecular function | 0.76 | ||
kinase perturbation | 0.66 | ||
chemical | 0.56 | ||
disease | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 970.97 (req: < 5)
Gene RIFs: 37 (req: <= 3)
Antibodies: 270 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 970.97 (req: >= 5)
Gene RIFs: 37 (req: > 3)
Antibodies: 270 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 283
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0