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Tchem
TDO2
Tryptophan 2,3-dioxygenase

Protein Summary
Description
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000536354
  • ENSP00000444788
  • ENSG00000151790
  • ENST00000573403
  • ENSP00000460086
  • ENSG00000262635

Symbol
  • TDO
  • TO
  • TDO
  • TPH2
  • TRPO
  • HYPTRP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.8
molecular function
0.76
kinase perturbation
0.66
chemical
0.56
disease
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 853.99   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 270   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 853.99   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 23
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
1
1
46
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
46
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tryptophan 2,3-dioxygenase
VGNC:12992
736252
Macaque
tryptophan 2,3-dioxygenase
699739
Mouse
MGI:1928486
56720
Rat
RGD:68370
64206
Dog
tryptophan 2,3-dioxygenase
VGNC:47217
475476
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tryptophan 2,3-dioxygenase
Macaque
tryptophan 2,3-dioxygenase
Mouse
Rat
Dog
tryptophan 2,3-dioxygenase
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P48775-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Tryptophan catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Tryptophan catabolism
Gene Ontology Terms (12)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (70)
1 – 10 of 70
ASMTL
Tbio
Family: Enzyme
Novelty: 0.17725871
p_int: 0.998130913
p_ni: 0.001869087
Score: 0.822
Data Source: BioPlex,STRINGDB
KYNU
Tchem
Family: Enzyme
Novelty: 0.01372383
Score: 0.996
Data Source: STRINGDB
IDO2
Tchem
Family: Enzyme
Novelty: 0.01141558
Score: 0.99
Data Source: STRINGDB
IDO1
Tchem
Family: Enzyme
Novelty: 0.00131229
Score: 0.985
Data Source: STRINGDB
AFMID
Tbio
Family: Enzyme
Novelty: 0.02027656
Score: 0.984
Data Source: STRINGDB
TPH1
Tclin
Family: Enzyme
Novelty: 0.00098637
Score: 0.965
Data Source: STRINGDB
KMO
Tchem
Family: Enzyme
Novelty: 0.01469543
Score: 0.949
Data Source: STRINGDB
TPH2
Tchem
Family: Enzyme
Novelty: 0.00265377
Score: 0.942
Data Source: STRINGDB
DDC
Tclin
Family: Enzyme
Novelty: 0.0012284
Score: 0.93
Data Source: STRINGDB
IL4I1
Tbio
Family: Enzyme
Novelty: 0.00414355
Score: 0.906
Data Source: STRINGDB
Publication Statistics
PubMed Score  853.99

PubMed score by year
PubTator Score  354.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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