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Tclin
SLC9A3
Sodium/hydrogen exchanger 3

Protein Summary
Description
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient (PubMed:26358773). Plays an important role in signal transduction. The protein encoded by this gene is an epithelial brush border Na/H exchanger that uses an inward sodium ion gradient to expel acids from the cell. Defects in this gene are a cause of congenital secretory sodium diarrhea. Pseudogenes of this gene exist on chromosomes 10 and 22. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264938
  • ENSP00000264938
  • ENSG00000066230
  • ENST00000514375
  • ENSP00000422983

Symbol
  • NHE3
  • NHE3
  • DIAR8
  • NHE-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.81
biological term
0.75
cell line
0.61
cellular component
0.61
disease
0.61


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 733.77   (req: < 5)
Gene RIFs: 69   (req: <= 3)
Antibodies: 284   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 733.77   (req: >= 5)
Gene RIFs: 69   (req: > 3)
Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 205
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
amiloride
chemical structure image
tenapanor
chemical structure image
Active Ligands (205)
1 – 10 of 205
CHEMBL3949677,CHEMBL3892788
chemical structure image
CHEMBL3976498
chemical structure image
CHEMBL3939789
chemical structure image
CHEMBL3905218
chemical structure image
CHEMBL3930910
chemical structure image
CHEMBL3977522
chemical structure image
CHEMBL3961582
chemical structure image
CHEMBL3928899
chemical structure image
CHEMBL3896021
chemical structure image
CHEMBL3968418
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lung disease associated with cystic fibrosis
1
1
1
51.3
glomerular filtration rate
1
1
1
18.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lung disease associated with cystic fibrosis
1
51.3
glomerular filtration rate
1
18.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 9 member A3
VGNC:13592
741885
Macaque
solute carrier family 9 member A3
708641
Mouse
MGI:105064
105243
Rat
RGD:3720
24784
Dog
solute carrier family 9 member A3
VGNC:53464
488073
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 9 member A3
Macaque
solute carrier family 9 member A3
Mouse
Rat
Dog
solute carrier family 9 member A3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P48764-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (59)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Sodium/Proton exchangers
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Sodium/Proton exchangers
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Protein-Protein Interactions (139)
1 – 10 of 139
EDN1
Tbio
Novelty: 0.00007453
Score: 0.959
Data Source: STRINGDB
EDNRB
Tclin
Family: GPCR
Novelty: 0.00053875
Score: 0.929
Data Source: STRINGDB
SLC9A3R2
Tbio
Family: Transporter
Novelty: 0.01401705
Score: 0.923
Data Source: STRINGDB
SLC9A3R1
Tbio
Family: Transporter
Novelty: 0.00357766
Score: 0.921
Data Source: STRINGDB
ROCK1
Tclin
Family: Kinase
Novelty: 0.00156045
Score: 0.915
Data Source: STRINGDB
CHP1
Tbio
Novelty: 0.01299969
Score: 0.912
Data Source: STRINGDB
ROCK2
Tclin
Family: Kinase
Novelty: 0.00242311
Score: 0.907
Data Source: STRINGDB
PDZK1
Tbio
Novelty: 0.01129974
Score: 0.876
Data Source: STRINGDB
LRP2
Tbio
Novelty: 0.00143258
Score: 0.856
Data Source: STRINGDB
SLC12A1
Tclin
Family: Transporter
Novelty: 0.00303604
Score: 0.845
Data Source: STRINGDB
Publication Statistics
PubMed Score  733.77

PubMed score by year
PubTator Score  314.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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