SLC9A3
Sodium/hydrogen exchanger 3
Protein Summary
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient (PubMed:26358773). Plays an important role in signal transduction. The protein encoded by this gene is an epithelial brush border Na/H exchanger that uses an inward sodium ion gradient to expel acids from the cell. Defects in this gene are a cause of congenital secretory sodium diarrhea. Pseudogenes of this gene exist on chromosomes 10 and 22. [provided by RefSeq, Mar 2016]
- ENST00000264938
- ENSP00000264938
- ENSG00000066230
- ENST00000514375
- ENSP00000422983
- NHE3
- NHE3
- DIAR8
- NHE-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.81 | ||
biological term | 0.75 | ||
cell line | 0.61 | ||
cellular component | 0.61 | ||
disease | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 799.93 (req: < 5)
Gene RIFs: 79 (req: <= 3)
Antibodies: 284 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 799.93 (req: >= 5)
Gene RIFs: 79 (req: > 3)
Antibodies: 284 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 240
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2