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Tbio
SLC4A3
Anion exchange protein 3

Protein Summary
Description
Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl(-). The protein encoded by this gene is a plasma membrane anion exchange protein. The encoded protein has been found in brain, heart, kidney, small intestine, and lung. [provided by RefSeq, May 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273063
  • ENSP00000273063
  • ENSG00000114923
  • ENST00000317151
  • ENSP00000314006
  • ENST00000358055
  • ENSP00000350756
  • ENST00000373760
  • ENSP00000362865

Symbol
  • AE3
  • AE3
  • SLC2C
  • CAE3/BAE3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
protein domain
0.92
disease perturbation
0.87
transcription factor
0.62
histone modification site profile
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.35   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 25   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.35   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
SLC26A6
Tbio
Family:  IC
Novelty:  0.00922143
Score:  0.722
Data Source:  STRINGDB
PRCD
Tdark
Novelty:  0.01755233
Score:  0.715
Data Source:  STRINGDB
AHCYL1
Tchem
Family:  Enzyme
Novelty:  0.02176432
Score:  0.692
Data Source:  STRINGDB
CHI3L2
Tbio
Family:  Enzyme
Novelty:  0.02130544
Score:  0.681
Data Source:  STRINGDB
SLC26A11
Tdark
Family:  Transporter
Novelty:  0.0959704
Score:  0.68
Data Source:  STRINGDB
LGI2
Tbio
Novelty:  0.09195527
Score:  0.645
Data Source:  STRINGDB
OSGEP
Tbio
Family:  Enzyme
Novelty:  0.0106198
Score:  0.639
Data Source:  STRINGDB
ASIC4
Tbio
Family:  IC
Novelty:  0.02912816
Score:  0.634
Data Source:  STRINGDB
SLC26A9
Tbio
Family:  Transporter
Novelty:  0.0354738
Score:  0.622
Data Source:  STRINGDB
CA2
Tclin
Family:  Enzyme
Novelty:  0.00040118
Score:  0.608
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Bicarbonate transporters (R-HSA-425381)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bicarbonate transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Bicarbonate transporters
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
60
71.9
QT interval
3
1
3
71.7
educational attainment
1
1
1
60
diastolic blood pressure
1
1
1
38.8
high density lipoprotein cholesterol measurement
6
1
6
20.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
60
71.9
QT interval
3
71.7
educational attainment
1
60
diastolic blood pressure
1
38.8
high density lipoprotein cholesterol measurement
6
20.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 4 member 3
VGNC:9062
459969
Macaque
solute carrier family 4 member 3
706115
Mouse
MGI:109350
20536
Rat
RGD:3712
24781
Dog
solute carrier family 4 member 3
VGNC:46433
488542
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 4 member 3
Macaque
solute carrier family 4 member 3
Mouse
Rat
Dog
solute carrier family 4 member 3
Publication Statistics
PubMed Score 21.35
PubMed score by year
PubTator Score 615.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title