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Tchem
MASP1
Mannan-binding lectin serine protease 1

Protein Summary
Description
Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development (PubMed:21258343). This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the man ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000169293
  • ENSP00000169293
  • ENSG00000127241
  • ENST00000296280
  • ENSP00000296280
  • ENST00000337774
  • ENSP00000336792
  • ENST00000392472
  • ENSP00000376264

Symbol
  • CRARF
  • CRARF1
  • PRSS5
  • 3MC1
  • MAP1
  • MASP
  • RaRF
  • CRARF
  • MASP3
  • MAp44
  • PRSS5
  • CRARF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor perturbation
0.88
microRNA
0.83
molecular function
0.67
disease
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 402.66   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 321   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 402.66   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
1
1
0
1.6
8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
1.6
8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mannan binding lectin serine peptidase 1
VGNC:11986
460925
Macaque
mannan binding lectin serine peptidase 1
708206
Mouse
MGI:88492
17174
Rat
RGD:620213
64023
Dog
mannan binding lectin serine peptidase 1
VGNC:43030
488121
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mannan binding lectin serine peptidase 1
Macaque
mannan binding lectin serine peptidase 1
Mouse
Rat
Dog
mannan binding lectin serine peptidase 1
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P48740-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Complement cascade
Reactome
Creation of C4 and C2 activators
Reactome
Ficolins bind to repetitive carbohydrate structures on the target cell surface
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors
Complement cascade
Creation of C4 and C2 activators
Ficolins bind to repetitive carbohydrate structures on the target cell surface
Immune System
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (61)
1 – 10 of 61
FCN2
Tbio
Novelty:  0.00519137
Score:  0.994
Data Source:  Reactome,STRINGDB
MBL2
Tbio
Novelty:  0.00124156
Score:  0.99
Data Source:  Reactome,STRINGDB
FCN1
Tbio
Novelty:  0.01037775
Score:  0.987
Data Source:  Reactome,STRINGDB
FCN3
Tbio
Novelty:  0.00771958
Score:  0.981
Data Source:  Reactome,STRINGDB
COLEC11
Tbio
Novelty:  0.02989413
Score:  0.976
Data Source:  Reactome,STRINGDB
C4B
Tbio
Novelty:  0.00068357
Score:  0.975
Data Source:  Reactome,STRINGDB
C4A
Tbio
Novelty:  0.00062793
Score:  0.967
Data Source:  Reactome,STRINGDB
COLEC10
Tbio
Novelty:  0.02593638
Score:  0.965
Data Source:  Reactome,STRINGDB
C2
Tchem
Novelty:  0.00974862
Score:  0.941
Data Source:  Reactome,STRINGDB
MASP2
Tchem
Family:  Enzyme
Novelty:  0.00466852
Score:  0.935
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  402.66

PubMed score by year
PubTator Score  201.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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