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Tchem
MASP1
Mannan-binding lectin serine protease 1

Protein Summary
Description
Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development (PubMed:21258343). This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the man ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000169293
  • ENSP00000169293
  • ENSG00000127241
  • ENST00000296280
  • ENSP00000296280
  • ENST00000337774
  • ENSP00000336792
  • ENST00000392472
  • ENSP00000376264

Symbol
  • CRARF
  • CRARF1
  • PRSS5
  • 3MC1
  • MAP1
  • MASP
  • RaRF
  • CRARF
  • MASP3
  • MAp44
  • PRSS5
  • CRARF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor perturbation
0.88
microRNA
0.83
molecular function
0.67
disease
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 489.08   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 321   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 489.08   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0