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Tbio
PITPNB
Phosphatidylinositol transfer protein beta isoform

Protein Summary
Description
Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes. This gene encodes a cytoplasmic protein that catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes. This transfer activity is required for COPI complex-mediated retrograde transport from the Golgi apparatus to the endoplasmic reticulum. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320996
  • ENSP00000321266
  • ENSG00000180957
  • ENST00000335272
  • ENSP00000334738
  • ENST00000634017
  • ENSP00000487693

Symbol
  • VIB1B
  • PtdInsTP
  • PI-TP-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
disease perturbation
0.98
kinase perturbation
0.96
histone modification site profile
0.87
interacting protein
0.86


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.57   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 249   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.57   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
OAT
Tchem
Family:  Enzyme
Novelty:  0.00125611
Score:  0.822
Data Source:  STRINGDB
TIA1
Tbio
Novelty:  0.00264338
Score:  0.812
Data Source:  STRINGDB
MPI
Tchem
Family:  Enzyme
Novelty:  0.0091718
Score:  0.81
Data Source:  STRINGDB
SEC14L6
Tdark
Novelty:  0.45648697
Score:  0.705
Data Source:  STRINGDB
ESD
Tchem
Family:  Enzyme
Novelty:  0.00519384
Score:  0.704
Data Source:  STRINGDB
ADK
Tchem
Family:  Kinase
Novelty:  0.00196435
Score:  0.683
Data Source:  STRINGDB
SEC14L3
Tbio
Novelty:  0.15067161
Score:  0.673
Data Source:  STRINGDB
SEC14L2
Tbio
Novelty:  0.0092728
Score:  0.647
Data Source:  STRINGDB
SLC35F6
Tbio
Family:  Transporter
Novelty:  1.05410124
Score:  0.628
Data Source:  STRINGDB
SEC14L5
Tdark
Novelty:  0.32185533
Score:  0.606
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
PI and PC transport between ER and Golgi membranes
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
PI Metabolism
PI and PC transport between ER and Golgi membranes
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
2
2
88.8
mean corpuscular hemoglobin concentration
1
1
1
77.3
mean reticulocyte volume
1
1
1
72.3
FEV/FEC ratio
1
1
1
71.3
platelet count
2
1
2
66.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
88.8
mean corpuscular hemoglobin concentration
1
77.3
mean reticulocyte volume
1
72.3
FEV/FEC ratio
1
71.3
platelet count
2
66.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol transfer protein beta
VGNC:5298
458731
Macaque
phosphatidylinositol transfer protein beta
713414
Mouse
MGI:1927542
56305
Rat
RGD:620143
114561
Dog
phosphatidylinositol transfer protein beta
VGNC:44584
609712
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol transfer protein beta
Macaque
phosphatidylinositol transfer protein beta
Mouse
Rat
Dog
phosphatidylinositol transfer protein beta
Publication Statistics
PubMed Score 35.57
PubMed score by year
PubTator Score 12.91
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title