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Tchem
CSNK1D
Casein kinase I isoform delta

Protein Summary
Description
Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314028
  • ENSP00000324464
  • ENSG00000141551
  • ENST00000392334
  • ENSP00000376146

Symbol
  • HCKID
  • ASPS
  • CKId
  • HCKID
  • FASPS2
  • CKIdelta
  • CKI-delta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
0.98
kinase perturbation
0.97
molecular function
0.96
hub protein
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.63   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 346   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.63   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 346   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 203
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
sunitinib
chemical structure image
Active Ligands (203)
1 – 10 of 203
CHEMBL1951415
chemical structure image
CHEMBL3958671,CHEMBL3889723
chemical structure image
CHEMBL3913933
chemical structure image
CHEMBL3889600
chemical structure image
CHEMBL3902838,CHEMBL3921603
chemical structure image
CHEMBL3916526,CHEMBL3948521
chemical structure image
CHEMBL3894506
chemical structure image
CHEMBL2203564
chemical structure image
CHEMBL2203556
chemical structure image
CHEMBL2420704
chemical structure image
Protein Data Bank (19)
1 – 5 of 19
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (82)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 29
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
Cell Cycle
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
Cell Cycle
Gene Ontology Terms (41)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (392)
1 – 10 of 392
CSNK1E
Tchem
Family: Kinase
Novelty: 0.00891859
p_int: 0.999999823
p_ni: 1.73e-7
p_wrong: 3e-9
Score: 0.981
Data Source: BioPlex,STRINGDB
SNX24
Tdark
Novelty: 0.20838126
p_int: 0.999991545
p_ni: 0.000008455
Score: 0.335
Data Source: BioPlex,STRINGDB
FAM110B
Tbio
Novelty: 0.35516609
p_int: 0.999988067
p_ni: 5.4e-8
p_wrong: 0.000011878
Score: 0.82
Data Source: BioPlex,STRINGDB
ZNF618
Tdark
Novelty: 0.43589506
p_int: 0.999986976
p_ni: 0.000012897
p_wrong: 1.27e-7
Score: 0.588
Data Source: BioPlex,STRINGDB
GAPVD1
Tbio
Family: Enzyme
Novelty: 0.13142098
p_int: 0.999986531
p_ni: 0.000013469
p_wrong: 1e-9
Score: 0.614
Data Source: BioPlex,STRINGDB
CRY2
Tbio
Novelty: 0.00156961
p_int: 0.999982271
p_ni: 0.000017729
Score: 0.994
Data Source: BioPlex,STRINGDB
CRY1
Tchem
Novelty: 0.00116593
p_int: 0.999979755
p_ni: 0.000020245
Score: 0.993
Data Source: BioPlex,STRINGDB
PER1
Tbio
Novelty: 0.01290576
p_int: 0.999964742
p_ni: 0.000035258
Score: 0.993
Data Source: BioPlex,STRINGDB
PDE4DIP
Tbio
Novelty: 0.03414104
p_int: 0.999959769
p_ni: 0.000040231
Score: 0.153
Data Source: BioPlex,STRINGDB
DBNDD1
Tdark
Novelty: 0.60202124
p_int: 0.999811622
p_ni: 0.000188378
Data Source: BioPlex
Publication Statistics
PubMed Score  94.63

PubMed score by year
PubTator Score  39.1

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer