CSNK1A1
Casein kinase I isoform alpha
Protein Summary
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).
- ENST00000261798
- ENSP00000261798
- ENSG00000113712
- ENST00000377843
- ENSP00000367074
- ENST00000515768
- ENSP00000421689
- CK1
- CK1a
- CKIa
- HLCDGP1
- PRO2975
- HEL-S-77p
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
interacting protein | 1 | ||
transcription factor perturbation | 1 | ||
hub protein | 0.97 | ||
kinase perturbation | 0.97 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 170.73 (req: < 5)
Gene RIFs: 65 (req: <= 3)
Antibodies: 608 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 170.73 (req: >= 5)
Gene RIFs: 65 (req: > 3)
Antibodies: 608 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 13
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0