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Tchem
CSNK1A1
Casein kinase I isoform alpha

Protein Summary
Description
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261798
  • ENSP00000261798
  • ENSG00000113712
  • ENST00000377843
  • ENSP00000367074
  • ENST00000515768
  • ENSP00000421689

Symbol
  • CK1
  • CK1a
  • CKIa
  • HLCDGP1
  • PRO2975
  • HEL-S-77p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
transcription factor perturbation
1
hub protein
0.97
kinase perturbation
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.12   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 608   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.12   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 608   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
2
46.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2
46.2
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (113)
AMER1 mutants destabilize the destruction complex (R-HSA-4839748)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AMER1 mutants destabilize the destruction complex
Reactome
APC truncation mutants have impaired AXIN binding
Reactome
AXIN missense mutants destabilize the destruction complex
Reactome
AXIN mutants destabilize the destruction complex, activating WNT signaling
Reactome
Activation of SMO
Name
Explore in Pharos
Explore in Source
AMER1 mutants destabilize the destruction complex
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
AXIN mutants destabilize the destruction complex, activating WNT signaling
Activation of SMO
Gene Ontology Terms (29)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (207)
1 – 10 of 207
FAM83G
Tbio
Novelty: 0.13274382
p_int: 0.999999993
p_ni: 3e-9
p_wrong: 4e-9
Score: 0.483
Data Source: BioPlex,STRINGDB
MDM4
Tchem
Novelty: 0.00321558
p_int: 0.999999992
p_ni: 8e-9
Score: 0.488
Data Source: BioPlex,STRINGDB
SNX24
Tdark
Novelty: 0.20838126
p_int: 0.999999981
p_ni: 1.9e-8
Score: 0.512
Data Source: BioPlex,STRINGDB
ZNF618
Tdark
Novelty: 0.43589506
p_int: 0.999999974
p_ni: 1.8e-8
p_wrong: 7e-9
Score: 0.358
Data Source: BioPlex,STRINGDB
FAM170A
Tdark
Novelty: 0.05778712
p_int: 0.999999971
p_ni: 2.9e-8
Score: 0.311
Data Source: BioPlex,STRINGDB
ZDBF2
Tdark
Novelty: 0.19205154
p_int: 0.9999828
p_ni: 0.000017059
p_wrong: 1.41e-7
Data Source: BioPlex
SSMEM1
Tdark
Novelty: 1.77966102
p_int: 0.999961821
p_ni: 0.000038179
Data Source: BioPlex
DBNDD1
Tdark
Novelty: 0.60202124
p_int: 0.999955178
p_ni: 0.000044823
Data Source: BioPlex
SPATA46
Tdark
Novelty: 0.327066
p_int: 0.999930053
p_ni: 0.000069946
Score: 0.821
Data Source: BioPlex,STRINGDB
RASAL2
Tbio
Family: Enzyme
Novelty: 0.03671142
p_int: 0.999923365
p_ni: 0.000005614
p_wrong: 0.000071021
Score: 0.532
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  149.12

PubMed score by year
PubTator Score  73.52

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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