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Tbio
AMT
Aminomethyltransferase, mitochondrial

Protein Summary
Description
The glycine cleavage system catalyzes the degradation of glycine. This gene encodes one of four critical components of the glycine cleavage system. Mutations in this gene have been associated with glycine encephalopathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273588
  • ENSP00000273588
  • ENSG00000145020
  • ENST00000395338
  • ENSP00000378747
  • ENST00000458307
  • ENSP00000415619
  • ENST00000636522
  • ENSP00000489758

Symbol
  • GCST
  • GCE
  • NKH
  • GCST
  • GCVT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
protein domain
0.85
cell type or tissue
0.65
transcription factor
0.63
tissue sample
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.23   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.23   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (87)
GLDC
Tbio
Family:  Enzyme
Novelty:  0.00900467
Score:  0.999
Data Source:  STRINGDB
GCSH
Tbio
Novelty:  0.02101972
Score:  0.999
Data Source:  Reactome,STRINGDB
SHMT2
Tchem
Family:  Enzyme
Novelty:  0.00234505
Score:  0.989
Data Source:  STRINGDB
DLD
Tbio
Family:  Enzyme
Novelty:  0.00214298
Score:  0.989
Data Source:  STRINGDB
SHMT1
Tbio
Family:  Enzyme
Novelty:  0.00200739
Score:  0.988
Data Source:  STRINGDB
MTHFD2
Tchem
Family:  Enzyme
Novelty:  0.01776594
Score:  0.979
Data Source:  STRINGDB
MTHFD2L
Tbio
Family:  Enzyme
Novelty:  0.18530504
Score:  0.976
Data Source:  STRINGDB
MTHFD1
Tchem
Family:  Enzyme
Novelty:  0.0071938
Score:  0.969
Data Source:  STRINGDB
MTHFD1L
Tbio
Family:  Enzyme
Novelty:  0.01548353
Score:  0.965
Data Source:  STRINGDB
ATIC
Tchem
Novelty:  0.00466845
Score:  0.962
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 3 of 3
DHFR
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
GART
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
TYMS
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (12)
Glycine degradation (R-HSA-6783984)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycine degradation
Reactome
Glyoxylate metabolism and glycine degradation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Glycine degradation
Glyoxylate metabolism and glycine degradation
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (35)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
4
12
5
6.5
98
self reported educational attainment
5
4
4
1
97.3
educational attainment
2
4
2
104.5
89.8
household income
1
4
4
89.7
lifestyle measurement
2
1
2
86.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
5
6.5
98
self reported educational attainment
4
1
97.3
educational attainment
2
104.5
89.8
household income
4
89.7
lifestyle measurement
2
86.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aminomethyltransferase
VGNC:1732
461012
Macaque
aminomethyltransferase
706515
Mouse
MGI:3646700
434437
Rat
RGD:1359408
306586
Dog
aminomethyltransferase
VGNC:54572
484770
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aminomethyltransferase
Macaque
aminomethyltransferase
Mouse
Rat
Dog
aminomethyltransferase
Publication Statistics
PubMed Score 98.23
PubMed score by year
PubTator Score 67.25
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text