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Tbio
AMT
Aminomethyltransferase, mitochondrial

Protein Summary
Description
The glycine cleavage system catalyzes the degradation of glycine. This gene encodes one of four critical components of the glycine cleavage system. Mutations in this gene have been associated with glycine encephalopathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273588
  • ENSP00000273588
  • ENSG00000145020
  • ENST00000395338
  • ENSP00000378747
  • ENST00000458307
  • ENSP00000415619
  • ENST00000636522
  • ENSP00000489758

Symbol
  • GCST
  • GCE
  • NKH
  • GCST
  • GCVT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
protein domain
0.85
cell type or tissue
0.65
transcription factor
0.63
tissue sample
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.97   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.97   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (12)
Glycine degradation (R-HSA-6783984)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycine degradation
Reactome
Glyoxylate metabolism and glycine degradation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Glycine degradation
Glyoxylate metabolism and glycine degradation
Metabolism
Metabolism of amino acids and derivatives
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (87)
1 – 10 of 87
GLDC
Tbio
Family: Enzyme
Novelty: 0.01431753
Score: 0.999
Data Source: STRINGDB
GCSH
Tbio
Novelty: 0.02430372
Score: 0.999
Data Source: Reactome,STRINGDB
SHMT2
Tbio
Family: Enzyme
Novelty: 0.00406219
Score: 0.989
Data Source: STRINGDB
DLD
Tbio
Family: Enzyme
Novelty: 0.00268083
Score: 0.989
Data Source: STRINGDB
SHMT1
Tbio
Family: Enzyme
Novelty: 0.00263085
Score: 0.988
Data Source: STRINGDB
MTHFD2
Tchem
Family: Enzyme
Novelty: 0.02582903
Score: 0.979
Data Source: STRINGDB
MTHFD2L
Tdark
Family: Enzyme
Novelty: 0.27741083
Score: 0.976
Data Source: STRINGDB
MTHFD1
Tbio
Family: Enzyme
Novelty: 0.00963399
Score: 0.969
Data Source: STRINGDB
MTHFD1L
Tbio
Family: Enzyme
Novelty: 0.02310578
Score: 0.965
Data Source: STRINGDB
ATIC
Tchem
Novelty: 0.00643735
Score: 0.962
Data Source: STRINGDB
Publication Statistics
PubMed Score  159.97

PubMed score by year
PubTator Score  67.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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