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Tbio
NES
Nestin

Protein Summary
Description
Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368223
  • ENSP00000357206
  • ENSG00000132688

Symbol
  • Nbla00170
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
1
PubMedID
0.9
transcription factor binding site profile
0.81
disease
0.8
drug perturbation
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2789.86   (req: < 5)
Gene RIFs: 193   (req: <= 3)
Antibodies: 988   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2789.86   (req: >= 5)
Gene RIFs: 193   (req: > 3)
Antibodies: 988   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nestin
VGNC:1346
742303
Macaque
nestin
718562
Mouse
MGI:101784
18008
Rat
RGD:3162
25491
Dog
nestin
VGNC:53625
490410
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nestin
Macaque
nestin
Mouse
Rat
Dog
nestin
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P48681-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (292)
1 – 10 of 292
VIM
Tbio
Novelty: 0.00030317
p_int: 0.999998286
p_ni: 0.00000171
p_wrong: 4e-9
Score: 0.864
Data Source: BioPlex,STRINGDB
NEFM
Tbio
Novelty: 0.00239134
p_int: 0.999996297
p_ni: 0.000003703
Score: 0.864
Data Source: BioPlex,STRINGDB
MYF6
Tbio
Family: TF
Novelty: 0.00509046
p_int: 0.999989783
p_ni: 0.000010217
Score: 0.706
Data Source: BioPlex,STRINGDB
RSPRY1
Tdark
Novelty: 0.26883105
p_int: 0.999979728
p_ni: 0.000020268
p_wrong: 5e-9
Score: 0.534
Data Source: BioPlex,STRINGDB
GFAP
Tbio
Novelty: 0.00020932
p_int: 0.999583129
p_ni: 0.000416871
Score: 0.805
Data Source: BioPlex,STRINGDB
FAM167A
Tbio
Novelty: 0.05232679
p_int: 0.998995089
p_ni: 0.001004908
p_wrong: 3e-9
Data Source: BioPlex
FERD3L
Tbio
Family: TF
Novelty: 0.06797434
p_int: 0.99466977
p_ni: 0.0053302
p_wrong: 3e-8
Score: 0.574
Data Source: BioPlex,STRINGDB
TCF4
Tbio
Family: TF
Novelty: 0.0019718
p_int: 0.993240337
p_ni: 0.006759217
p_wrong: 4.46e-7
Score: 0.881
Data Source: BioPlex,STRINGDB
SYNC
Tbio
Novelty: 0.04605223
p_int: 0.991298502
p_ni: 0.008688095
p_wrong: 0.000013403
Score: 0.706
Data Source: BioPlex,STRINGDB
CAPN1
Tchem
Novelty: 0.00252811
p_int: 0.982028998
p_ni: 0.017970681
p_wrong: 3.21e-7
Score: 0.647
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  2789.86

PubMed score by year
PubTator Score  436.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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