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Tchem
SLC1A6
Excitatory amino acid transporter 4

Protein Summary
Description
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7791878). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (Probable).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221742
  • ENSP00000221742
  • ENSG00000105143
  • ENST00000544886
  • ENSP00000446175
  • ENST00000598504
  • ENSP00000471781

Symbol
  • EAAT4
  • EAAT4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
cellular component
0.56
gene perturbation
0.49
metabolite
0.45
pathway
0.45


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.8   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.8   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1096331
20513
Rat
RGD:620340
84012
Dog
solute carrier family 1 member 6
VGNC:46266
403749
Horse
solute carrier family 1 member 6 [Source:HGNC Symbol;Acc:HGNC:10944]
Cow
solute carrier family 1 member 6
VGNC:52881
538673
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
solute carrier family 1 member 6
Horse
solute carrier family 1 member 6 [Source:HGNC Symbol;Acc:HGNC:10944]
Cow
solute carrier family 1 member 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P48664-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Glutamate Neurotransmitter Release Cycle (R-HSA-210500)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glutamate Neurotransmitter Release Cycle
Reactome
Neuronal System
Reactome
Neurotransmitter release cycle
Reactome
SLC-mediated transmembrane transport
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
Glutamate Neurotransmitter Release Cycle
Neuronal System
Neurotransmitter release cycle
SLC-mediated transmembrane transport
Transmission across Chemical Synapses
Gene Ontology Terms (19)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (80)
1 – 10 of 80
ARHGEF11
Tbio
Novelty:  0.01942359
Score:  0.873
Data Source:  STRINGDB
SLC1A1
Tchem
Family:  Transporter
Novelty:  0.00218479
Score:  0.815
Data Source:  STRINGDB
SPTBN2
Tbio
Novelty:  0.01183066
Score:  0.807
Data Source:  STRINGDB
SLC38A2
Tbio
Family:  Transporter
Novelty:  0.00808235
Score:  0.743
Data Source:  STRINGDB
SLC3A2
Tbio
Family:  Transporter
Novelty:  0.0021506
Score:  0.703
Data Source:  STRINGDB
SLC7A5
Tchem
Family:  Transporter
Novelty:  0.00365806
Score:  0.689
Data Source:  STRINGDB
SLC3A1
Tbio
Family:  Transporter
Novelty:  0.003328
Score:  0.651
Data Source:  STRINGDB
SLC15A1
Tchem
Family:  Transporter
Novelty:  0.00149723
Score:  0.64
Data Source:  STRINGDB
SLC7A8
Tbio
Family:  Transporter
Novelty:  0.03433454
Score:  0.634
Data Source:  STRINGDB
SLC6A19
Tchem
Family:  Transporter
Novelty:  0.01581031
Score:  0.632
Data Source:  STRINGDB
Publication Statistics
PubMed Score  90.80

PubMed score by year
PubTator Score  44.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer