Protein Summary
Neuromedin-U-25: Ligand for receptors NMUR1 and NMUR2 (By similarity). Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder. Neuromedin precursor-related peptide 33: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36. Neuromedin precursor-related peptide 36: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system. This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene w ...more
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.82 | ||
PubMedID | 0.76 | ||
histone modification site profile | 0.69 | ||
small molecule perturbation | 0.66 | ||
tissue | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 349.03 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 155 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 349.03 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 155 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (371)
HFE
Novelty: 0.00042077
p_int: 0.999964668
p_ni: 0.000035273
p_wrong: 5.9e-8
Data Source: BioPlex
GINM1
Novelty: 1.0701107
p_int: 0.999887578
p_ni: 0.000076846
p_wrong: 0.000035576
Data Source: BioPlex
HLA-DPA1
Novelty: 0.01080446
p_int: 0.999414358
p_ni: 0.00058562
p_wrong: 2.2e-8
Data Source: BioPlex
TMEM106A
Novelty: 0.32470607
p_int: 0.997791243
p_ni: 0.002147408
p_wrong: 0.00006135
Data Source: BioPlex
MANSC1
Novelty: 0.91681036
p_int: 0.99760149
p_ni: 0.000466364
p_wrong: 0.001932146
Data Source: BioPlex
IL20RB
Novelty: 0.01747619
p_int: 0.997241854
p_ni: 0.001040157
p_wrong: 0.001717989
Score: 0.188
Data Source: BioPlex,STRINGDB
CSTL1
Novelty: 0.13370814
p_int: 0.996801619
p_ni: 0.000567522
p_wrong: 0.002630859
Data Source: BioPlex
MGAT4C
Family: Enzyme
Novelty: 0.19680806
p_int: 0.993833123
p_ni: 0.006164772
p_wrong: 0.000002106
Data Source: BioPlex
PCDHA4
Novelty: 0.30511211
p_int: 0.992476274
p_ni: 0.007507833
p_wrong: 0.000015892
Data Source: BioPlex
PCDH20
Novelty: 0.07862843
p_int: 0.991508376
p_ni: 0.008483344
p_wrong: 0.00000828
Data Source: BioPlex
Nearest Tclin Targets
Pathways (9)
Reactome (8)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (i) signalling events | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (4)
Components (2)
Processes (22)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 2 | 2 | 2 | 75 | |||||
waist-hip ratio | 1 | 2 | 2 | 67.3 | |||||
body height | 2 | 2 | 2 | 58.9 | |||||
hip circumference | 1 | 1 | 1 | 52.4 | |||||
lymphocyte count | 1 | 1 | 1 | 44.2 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 2 | 75 | |||||
waist-hip ratio | 2 | 67.3 | |||||
body height | 2 | 58.9 | |||||
hip circumference | 1 | 52.4 | |||||
lymphocyte count | 1 | 44.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | neuromedin U | VGNC:652 | 737254 | |||||
Mouse | MGI:1860476 | 56183 | ||||||
Rat | RGD:68388 | 63887 | ||||||
Horse | neuromedin U | VGNC:51270 | 102148328 | |||||
Cow | neuromedin U | VGNC:32139 | 782109 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | neuromedin U | |||||
Mouse | ||||||
Rat | ||||||
Horse | neuromedin U | |||||
Cow | neuromedin U | |||||
Publication Statistics
PubMed Score 349.03
PubMed score by year
PubTator Score 82.18
PubTator score by year
Related Publications
Text Mined References (40)
GeneRif Annotations (20)
Items per page:
0 of 0
PMID | Year | Title |
---|