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Tbio
NMU
Neuromedin-U

Protein Classes
Protein Summary
Description
Neuromedin-U-25: Ligand for receptors NMUR1 and NMUR2 (By similarity). Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder. Neuromedin precursor-related peptide 33: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36. Neuromedin precursor-related peptide 36: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system. This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene w ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264218
  • ENSP00000264218
  • ENSG00000109255
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.82
PubMedID
0.76
histone modification site profile
0.69
small molecule perturbation
0.66
tissue
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 349.03   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 349.03   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
2
2
75
waist-hip ratio
1
2
2
67.3
body height
2
2
2
58.9
hip circumference
1
1
1
52.4
lymphocyte count
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
75
waist-hip ratio
2
67.3
body height
2
58.9
hip circumference
1
52.4
lymphocyte count
1
44.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuromedin U
VGNC:652
737254
Mouse
MGI:1860476
56183
Rat
RGD:68388
63887
Horse
neuromedin U
VGNC:51270
102148328
Cow
neuromedin U
VGNC:32139
782109
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuromedin U
Mouse
Rat
Horse
neuromedin U
Cow
neuromedin U
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P48645-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Protein-Protein Interactions (371)
1 – 10 of 371
HFE
Tbio
Novelty:  0.00042077
p_int:  0.999964668
p_ni:  0.000035273
p_wrong:  5.9e-8
Data Source:  BioPlex
GINM1
Tdark
Novelty:  1.0701107
p_int:  0.999887578
p_ni:  0.000076846
p_wrong:  0.000035576
Data Source:  BioPlex
HLA-DPA1
Tbio
Novelty:  0.01080446
p_int:  0.999414358
p_ni:  0.00058562
p_wrong:  2.2e-8
Data Source:  BioPlex
TMEM106A
Tbio
Novelty:  0.32470607
p_int:  0.997791243
p_ni:  0.002147408
p_wrong:  0.00006135
Data Source:  BioPlex
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.99760149
p_ni:  0.000466364
p_wrong:  0.001932146
Data Source:  BioPlex
IL20RB
Tbio
Novelty:  0.01747619
p_int:  0.997241854
p_ni:  0.001040157
p_wrong:  0.001717989
Score:  0.188
Data Source:  BioPlex,STRINGDB
CSTL1
Tbio
Novelty:  0.13370814
p_int:  0.996801619
p_ni:  0.000567522
p_wrong:  0.002630859
Data Source:  BioPlex
MGAT4C
Tdark
Family:  Enzyme
Novelty:  0.19680806
p_int:  0.993833123
p_ni:  0.006164772
p_wrong:  0.000002106
Data Source:  BioPlex
PCDHA4
Tdark
Novelty:  0.30511211
p_int:  0.992476274
p_ni:  0.007507833
p_wrong:  0.000015892
Data Source:  BioPlex
PCDH20
Tbio
Novelty:  0.07862843
p_int:  0.991508376
p_ni:  0.008483344
p_wrong:  0.00000828
Data Source:  BioPlex
Publication Statistics
PubMed Score  349.03

PubMed score by year
PubTator Score  82.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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