Tbio NMU Neuromedin-U

Protein Classes

DTO Classes

Neuromedin-u Receptor 2 / Neuromedin-u Receptor 1

Protein Summary

Description

Neuromedin-U-25: Ligand for receptors NMUR1 and NMUR2 (By similarity). Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder. Neuromedin precursor-related peptide 33: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36. Neuromedin precursor-related peptide 36: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system. This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide. [provided by RefSeq, Jul 2015]

Uniprot Accession IDs

• P48645

Gene Name

• NMU

Ensembl ID

• ENST00000264218
• ENSP00000264218
• ENSG00000109255

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.82
PubMedID	0.76
histone modification site profile	0.69
small molecule perturbation	0.66
tissue	0.56

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 349.03   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 155   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 349.03   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (11)

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1 – 5 of 11

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist-hip ratio	EFO_0007788	2	2	2		75
waist-hip ratio	EFO_0004343	1	2	2		67.3
body height	EFO_0004339	2	2	2		58.9
hip circumference	EFO_0005093	1	1	1		52.4
lymphocyte count	EFO_0004587	1	1	1		44.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 11

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist-hip ratio	EFO_0007788	2		75
waist-hip ratio	EFO_0004343	2		67.3
body height	EFO_0004339	2		58.9
hip circumference	EFO_0005093	1		52.4
lymphocyte count	EFO_0004587	1		44.2

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Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	neuromedin U	VGNC:652	737254
Mouse	neuromedin U	MGI:1860476	56183
Rat	neuromedin U	RGD:68388	63887
Horse	neuromedin U	VGNC:51270	102148328
Cow	neuromedin U	VGNC:32139	782109

Species	Name	OMA	EggNOG	Inparanoid
Chimp	neuromedin U
Mouse	neuromedin U
Rat	neuromedin U
Horse	neuromedin U
Cow	neuromedin U

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-P48645-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)

Reactome (8)

KEGG (1)

Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Reactome	G alpha (i) signalling events	408 targets	R-HSA-418594
Reactome	G alpha (q) signalling events	219 targets	R-HSA-416476
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396
Reactome	GPCR ligand binding	460 targets	R-HSA-500792

Name	Explore in Pharos	Explore in Source
Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
G alpha (i) signalling events	408 targets	R-HSA-418594
G alpha (q) signalling events	219 targets	R-HSA-416476
GPCR downstream signalling	1152 targets	R-HSA-388396
GPCR ligand binding	460 targets	R-HSA-500792

Gene Ontology Terms (28)

Functions (4)

Components (2)

Processes (22)

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1 – 4 of 4

GO Term	Evidence	Assigned by
type 1 neuromedin U receptor binding	Inferred from Direct Assay (IDA)	UniProtKB
type 2 neuromedin U receptor binding	Inferred from Direct Assay (IDA)	UniProtKB
neuromedin U receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
signaling receptor binding	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (371)

Explore Interacting Targets

1 – 10 of 371

• See Interactions on String-DB

HFE

Tbio

Novelty:  0.00042077

p_int:  0.999964668

p_ni:  0.000035273

p_wrong:  5.9e-8

Data Source:  BioPlex

GINM1

Tdark

Novelty:  1.0701107

p_int:  0.999887578

p_ni:  0.000076846

p_wrong:  0.000035576

Data Source:  BioPlex

HLA-DPA1

Tbio

Novelty:  0.01080446

p_int:  0.999414358

p_ni:  0.00058562

p_wrong:  2.2e-8

Data Source:  BioPlex

TMEM106A

Tbio

Novelty:  0.32470607

p_int:  0.997791243

p_ni:  0.002147408

p_wrong:  0.00006135

Data Source:  BioPlex

MANSC1

Tdark

Novelty:  0.91681036

p_int:  0.99760149

p_ni:  0.000466364

p_wrong:  0.001932146

Data Source:  BioPlex

IL20RB

Tbio

Novelty:  0.01747619

p_int:  0.997241854

p_ni:  0.001040157

p_wrong:  0.001717989

Score:  0.188

Data Source:  BioPlex,STRINGDB

CSTL1

Tbio

Novelty:  0.13370814

p_int:  0.996801619

p_ni:  0.000567522

p_wrong:  0.002630859

Data Source:  BioPlex

MGAT4C

Tdark

Family:  Enzyme

Novelty:  0.19680806

p_int:  0.993833123

p_ni:  0.006164772

p_wrong:  0.000002106

Data Source:  BioPlex

PCDHA4

Tdark

Novelty:  0.30511211

p_int:  0.992476274

p_ni:  0.007507833

p_wrong:  0.000015892

Data Source:  BioPlex

PCDH20

Tbio

Novelty:  0.07862843

p_int:  0.991508376

p_ni:  0.008483344

p_wrong:  0.00000828

Data Source:  BioPlex

Publication Statistics

PubMed Score  349.03

PubMed score by year

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PubTator Score  82.18

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
Amidation
Cleavage on pair of basic residues
Complete proteome
Neuropeptide
Oxidation
Polymorphism
Reference proteome
Secreted
Signal

GWAS Trait Find Similar Targets

No Header	No Header
albuminuria
balding measurement
BMI-adjusted hip circumference
BMI-adjusted waist-hip ratio
body height
hip circumference
lymphocyte count
neutrophil percentage of leukocytes
urinary albumin to creatinine ratio
waist circumference

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
behavior/neurological phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
immune system phenotype
liver/biliary system phenotype