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Tbio
GSS
Glutathione synthetase

Protein Classes
Protein Summary
Description
Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216951
  • ENSP00000216951
  • ENSG00000100983
  • ENST00000451957
  • ENSP00000407517
  • ENST00000643188
  • ENSP00000493903
  • ENST00000644793
  • ENSP00000495750
  • ENST00000646735
  • ENSP00000493763

Symbol
  • GSHS
  • HEL-S-64p
  • HEL-S-88n
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
disease perturbation
0.98
kinase perturbation
0.98
transcription factor perturbation
0.96
histone modification site profile
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.07   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 368   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.07   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 368   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
2
2
8.6
92.4
appendicular lean mass
3
2
5
91.9
suntan
1
1
1
88.3
BMI-adjusted hip circumference
2
4
5
86.8
heel bone mineral density
2
2
3
81
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
8.6
92.4
appendicular lean mass
5
91.9
suntan
1
88.3
BMI-adjusted hip circumference
5
86.8
heel bone mineral density
3
81
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutathione synthetase
VGNC:9866
745328
Macaque
glutathione synthetase
706600
Mouse
MGI:95852
14854
Rat
RGD:2752
25458
Dog
glutathione synthetase
VGNC:41534
442962
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutathione synthetase
Macaque
glutathione synthetase
Mouse
Rat
Dog
glutathione synthetase
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P48637-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (33)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Reactome
Disease
Reactome
Diseases of metabolism
Reactome
Glutathione conjugation
Name
Explore in Pharos
Explore in Source
Biological oxidations
Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Disease
Diseases of metabolism
Glutathione conjugation
Gene Ontology Terms (19)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (83)
1 – 10 of 83
GCLC
Tchem
Family:  Enzyme
Novelty:  0.00217206
Score:  0.986
Data Source:  STRINGDB
GSR
Tclin
Family:  Enzyme
Novelty:  0.00040107
Score:  0.985
Data Source:  STRINGDB
GCLM
Tbio
Family:  Enzyme
Novelty:  0.00395815
Score:  0.974
Data Source:  STRINGDB
GPX1
Tbio
Family:  Enzyme
Novelty:  0.000826
Score:  0.954
Data Source:  STRINGDB
GPX4
Tbio
Family:  Enzyme
Novelty:  0.00188213
Score:  0.951
Data Source:  STRINGDB
GPX5
Tbio
Family:  Enzyme
Novelty:  0.01204448
Score:  0.951
Data Source:  STRINGDB
GPX2
Tbio
Family:  Enzyme
Novelty:  0.00479104
Score:  0.949
Data Source:  STRINGDB
GGT6
Tbio
Family:  Enzyme
Novelty:  0.016069
Score:  0.949
Data Source:  STRINGDB
GGT7
Tbio
Family:  Enzyme
Novelty:  0.01374716
Score:  0.949
Data Source:  STRINGDB
GGT1
Tbio
Family:  Enzyme
Novelty:  0.00252374
Score:  0.946
Data Source:  STRINGDB
Publication Statistics
PubMed Score  30.07

PubMed score by year
PubTator Score  264.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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