GSS
Glutathione synthetase
Protein Summary
Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq, Jul 2008]
- ENST00000216951
- ENSP00000216951
- ENSG00000100983
- ENST00000451957
- ENSP00000407517
- ENST00000643188
- ENSP00000493903
- ENST00000644793
- ENSP00000495750
- ENST00000646735
- ENSP00000493763
- GSHS
- HEL-S-64p
- HEL-S-88n
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 1 | ||
disease perturbation | 0.98 | ||
kinase perturbation | 0.98 | ||
transcription factor perturbation | 0.96 | ||
histone modification site profile | 0.91 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 67.75 (req: < 5)
Gene RIFs: 25 (req: <= 3)
Antibodies: 368 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 67.75 (req: >= 5)
Gene RIFs: 25 (req: > 3)
Antibodies: 368 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0