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Tbio
SERPINB10
Serpin B10

Protein Summary
Description
Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus. This gene is a member of the serpin peptidase inhibitor, clade B family and is found in a cluster of other similar genes on chromosome 18. The protein encoded by this gene appears to help control the regulation of protease functions during hematopoiesis. Variations in this gene may increase the risk of prostate cancer. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000238508
  • ENSP00000238508
  • ENSG00000242550
  • ENST00000619595
  • ENSP00000479385

Symbol
  • PI10
  • PI10
  • PI-10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.97
gene perturbation
0.63
cell line
0.6
protein domain
0.41
protein complex
0.4


Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.53   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.53   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serpin family B member 10
VGNC:7331
107966356
Macaque
serpin family B member 10
100430164
Mouse
MGI:2138648
241197
Rat
RGD:628853
266775
Dog
serpin family B member 10
VGNC:46027
483951
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serpin family B member 10
Macaque
serpin family B member 10
Mouse
Rat
Dog
serpin family B member 10
Pathways (4)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (10)
1 – 10 of 10
CTSG
Tchem
Family: Enzyme
Novelty: 0.00102052
Score: 0.833
Data Source: STRINGDB
HAPLN3
Tdark
Novelty: 0.19545048
Score: 0.567
Data Source: STRINGDB
LACRT
Tbio
Novelty: 0.03333799
Score: 0.546
Data Source: STRINGDB
PI15
Tbio
Family: Enzyme
Novelty: 0.02244161
Score: 0.537
Data Source: STRINGDB
LYG2
Tbio
Family: Enzyme
Novelty: 0.12091256
Score: 0.485
Data Source: STRINGDB
SYDE2
Tdark
Family: Enzyme
Novelty: 1.77288781
Score: 0.479
Data Source: STRINGDB
XPA
Tbio
Novelty: 0.00137698
Score: 0.447
Data Source: STRINGDB
RSPH1
Tbio
Novelty: 0.02982525
Score: 0.446
Data Source: STRINGDB
SOGA3
Tdark
Novelty: 2.17187131
Score: 0.439
Data Source: STRINGDB
ACOT7
Tbio
Family: Enzyme
Novelty: 0.01093954
Score: 0.407
Data Source: STRINGDB
Publication Statistics
PubMed Score  77.53

PubMed score by year
PubTator Score  33.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer