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Tbio
NRIP1
Nuclear receptor-interacting protein 1

Protein Summary
Description
Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318948
  • ENSP00000327213
  • ENSG00000180530
  • ENST00000400199
  • ENSP00000383060
  • ENST00000400202
  • ENSP00000383063

Symbol
  • CAKUT3
  • RIP140
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
PubMedID
0.91
small molecule perturbation
0.89
transcription factor perturbation
0.88
hub protein
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.12   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.12   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
3
1
3
91.8
refractive error measurement
2
1
1
6.1
80.9
monocyte count
2
1
2
79.3
birth weight
3
1
3
59.2
red blood cell distribution width
1
1
1
48.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
3
91.8
refractive error measurement
1
6.1
80.9
monocyte count
2
79.3
birth weight
3
59.2
red blood cell distribution width
1
48.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
nuclear receptor interacting protein 1
693866
Mouse
MGI:1315213
268903
Rat
RGD:1311850
304157
Dog
nuclear receptor interacting protein 1
VGNC:43969
478385
Horse
nuclear receptor interacting protein 1
VGNC:20886
100054242
Species
Name
OMA
EggNOG
Inparanoid
Macaque
nuclear receptor interacting protein 1
Mouse
Rat
Dog
nuclear receptor interacting protein 1
Horse
nuclear receptor interacting protein 1
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (102)
Circadian Clock (R-HSA-400253)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Circadian Clock
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Circadian Clock
ESR-mediated signaling
Estrogen-dependent gene expression
Metabolism of proteins
Post-translational protein modification
Gene Ontology Terms (24)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (145)
1 – 10 of 145
TNNC2
Tbio
Novelty: 0.07759506
p_int: 0.999999949
p_ni: 2.9e-8
p_wrong: 2.3e-8
Data Source: BioPlex
MAGEA10
Tbio
Novelty: 0.05364393
p_int: 0.999997981
p_ni: 0.000001816
p_wrong: 2.03e-7
Score: 0.209
Data Source: BioPlex,STRINGDB
ESR1
Tclin
Family: NR
Novelty: 0.00005938
Score: 0.98
Data Source: STRINGDB
RXRA
Tclin
Family: NR
Novelty: 0.00244343
Score: 0.98
Data Source: Reactome,STRINGDB
NCOR1
Tchem
Family: TF
Novelty: 0.0021926
Score: 0.975
Data Source: STRINGDB
NR1H3
Tchem
Family: NR
Novelty: 0.00394862
Score: 0.971
Data Source: Reactome,STRINGDB
NCOA1
Tchem
Family: Epigenetic
Novelty: 0.00344663
Score: 0.971
Data Source: STRINGDB
NCOR2
Tchem
Family: TF
Novelty: 0.00066449
Score: 0.97
Data Source: STRINGDB
PPARA
Tclin
Family: NR
Novelty: 0.00017403
Score: 0.969
Data Source: STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
Score: 0.968
Data Source: STRINGDB
Publication Statistics
PubMed Score  216.12

PubMed score by year
PubTator Score  121.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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