Tclin IFNAR2 Interferon alpha/beta receptor 2

Protein Summary

Description

Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950). The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P48551
• A8KAJ4
• D3DSE8
• D3DSE9
• Q15467
• Q6FHD7
• IFN-R-2

Gene Name

• IFNAR2

Ensembl ID

• ENST00000342101
• ENSP00000343289
• ENSG00000159110
• ENST00000342136
• ENSP00000343957
• ENST00000382264
• ENSP00000371699
• ENST00000404220
• ENSP00000384309

Symbol

• IFNABR
• IFNARB
• IFN-R
• IMD45
• IFNABR
• IFNARB
• IFN-alpha-REC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.83
hub protein	0.82
transcription factor binding site profile	0.8
PubMedID	0.78
kinase perturbation	0.71

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Type Ii Cytokine Receptor / Interferon Alpha/beta Receptor 2

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Interferon Alpha/beta Receptor 2

Protein / Defense/immunity Protein / Interferon Alpha/beta Receptor 2

DTO Classes

Protein / Receptor / Cytokine Receptor / Type Ii Cytokine Receptor / Interferon Alpha/beta Receptor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 234.61   (req: < 5)

Gene RIFs: 67   (req: <= 3)

Antibodies: 352   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 234.61   (req: >= 5)

Gene RIFs: 67   (req: > 3)

Antibodies: 352   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6