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Tclin
IFNAR2
Interferon alpha/beta receptor 2

Protein Summary
Description
Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950). The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342101
  • ENSP00000343289
  • ENSG00000159110
  • ENST00000342136
  • ENSP00000343957
  • ENST00000382264
  • ENSP00000371699
  • ENST00000404220
  • ENSP00000384309

Symbol
  • IFNABR
  • IFNARB
  • IFN-R
  • IMD45
  • IFNABR
  • IFNARB
  • IFN-alpha-REC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.83
hub protein
0.82
transcription factor binding site profile
0.8
PubMedID
0.78
kinase perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.61   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 352   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.61   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 352   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin-10 receptor B measurement
1
1
1
64
COVID-19
1
1
0
1.2
52.7
eosinophil count
1
1
1
42.3
eosinophil percentage of leukocytes
1
1
1
38.8
1
1
0
1.3
2.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin-10 receptor B measurement
1
64
COVID-19
0
1.2
52.7
eosinophil count
1
42.3
eosinophil percentage of leukocytes
1
38.8
0
1.3
2.2
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interferon alpha and beta receptor subunit 2
VGNC:7182
473965
Macaque
interferon alpha and beta receptor subunit 2
699726
Mouse
MGI:1098243
15976
Rat
RGD:1583177
686326
Dog
interferon alpha and beta receptor subunit 2
100856468
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interferon alpha and beta receptor subunit 2
Macaque
interferon alpha and beta receptor subunit 2
Mouse
Rat
Dog
interferon alpha and beta receptor subunit 2
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P48551-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (37)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon alpha/beta signaling
Reactome
Regulation of IFNA signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon alpha/beta signaling
Regulation of IFNA signaling
Protein-Protein Interactions (124)
1 – 10 of 124
GRAP2
Tbio
Novelty:  0.00503901
p_int:  0.9994602
p_ni:  0.0005398
Score:  0.307
Data Source:  BioPlex,STRINGDB
IFNAR1
Tclin
Novelty:  0.00175488
Score:  0.998
Data Source:  Reactome,STRINGDB
IFNA2
Tbio
Novelty:  0.00032935
Score:  0.993
Data Source:  STRINGDB
STAT2
Tbio
Family:  TF
Novelty:  0.00241454
Score:  0.99
Data Source:  Reactome,STRINGDB
JAK1
Tclin
Family:  Kinase
Novelty:  0.00093625
Score:  0.987
Data Source:  Reactome,STRINGDB
IFNW1
Tbio
Novelty:  0.1308421
Score:  0.984
Data Source:  STRINGDB
IRF9
Tbio
Family:  TF
Novelty:  0.00751233
Score:  0.982
Data Source:  STRINGDB
STAT1
Tchem
Family:  TF
Novelty:  0.0003383
Score:  0.981
Data Source:  Reactome,STRINGDB
TYK2
Tclin
Family:  Kinase
Novelty:  0.00237955
Score:  0.981
Data Source:  Reactome,STRINGDB
IFNB1
Tbio
Novelty:  0.00011797
Score:  0.975
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  200.61

PubMed score by year
PubTator Score  153.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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