KCNJ3
G protein-activated inward rectifier potassium channel 1
Protein Summary
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three ...more
- ENST00000295101
- ENSP00000295101
- ENSG00000162989
- ENST00000544049
- ENSP00000438410
- GIRK1
- KGA
- GIRK1
- KIR3.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.9 | ||
disease perturbation | 0.68 | ||
PubMedID | 0.66 | ||
disease | 0.63 | ||
microRNA | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 268.87 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 407 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 268.87 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 407 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (4)
Protein-Protein Interactions (117)
KCNJ5
Family: IC
Novelty: 0.00385775
p_int: 0.999983481
p_wrong: 0.000016519
Score: 0.876
Data Source: BioPlex,Reactome,STRINGDB
Nearest Tclin Targets (14)
Upstream (14)
1 – 5 of 14
Pathways (27)
Reactome (11)
KEGG (10)
PathwayCommons (4)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of G protein gated Potassium channels | ||||
Reactome | Activation of GABAB receptors | ||||
Reactome | G protein gated Potassium channels | ||||
Reactome | GABA B receptor activation | ||||
Reactome | GABA receptor activation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of G protein gated Potassium channels | ||||
Activation of GABAB receptors | ||||
G protein gated Potassium channels | ||||
GABA B receptor activation | ||||
GABA receptor activation | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (4)
Components (6)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred by Curator (IC) | BHF-UCL | |||
Inferred by Curator (IC) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 4 | 4 | 3 | 5.8 | 81.3 | ||||
smoking status measurement | 2 | 1 | 2 | 73 | |||||
intelligence | 5 | 7 | 2 | 5.9 | 73 | ||||
mean platelet volume | 2 | 1 | 2 | 68.6 | |||||
smoking initiation | 2 | 2 | 2 | 44 | |||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
self reported educational attainment | 3 | 5.8 | 81.3 | ||||
smoking status measurement | 2 | 73 | |||||
intelligence | 2 | 5.9 | 73 | ||||
mean platelet volume | 2 | 68.6 | |||||
smoking initiation | 2 | 44 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | potassium voltage-gated channel subfamily J member 3 | VGNC:8360 | 737029 | |||||
Macaque | potassium voltage-gated channel subfamily J member 3 | 696473 | ||||||
Mouse | MGI:104742 | 16519 | ||||||
Rat | RGD:2958 | 50599 | ||||||
Dog | potassium voltage-gated channel subfamily J member 3 | VGNC:42264 | 488355 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | potassium voltage-gated channel subfamily J member 3 | |||||
Macaque | potassium voltage-gated channel subfamily J member 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | potassium voltage-gated channel subfamily J member 3 | |||||
Publication Statistics
PubMed Score 268.87
PubMed score by year
PubTator Score 123.21
PubTator score by year
Patents
Patents by year
Related Publications
GeneRif Annotations (21)
Items per page:
0 of 0
PMID | Text |
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