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Tclin
KCNC1
Potassium voltage-gated channel subfamily C member 1

Protein Summary
Description
Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient (PubMed:25401298). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons. This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both "b" and "alpha", wh ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265969
  • ENSP00000265969
  • ENSG00000129159
  • ENST00000379472
  • ENSP00000368785

Symbol
  • KV4
  • EPM7
  • NGK2
  • KV3.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.88
cellular component
0.76
gene perturbation
0.74
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 380.71   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 381   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 380.71   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 381   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
57.8
energy expenditure measurement
1
1
0
63
39.7
alcohol consumption measurement
1
1
1
14.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
57.8
energy expenditure measurement
0
63
39.7
alcohol consumption measurement
1
14.9
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily C member 1
VGNC:11848
466452
Macaque
potassium voltage-gated channel subfamily C member 1
696106
Mouse
MGI:96667
16502
Rat
RGD:2955
25327
Dog
potassium voltage-gated channel subfamily C member 1
VGNC:42236
403705
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily C member 1
Macaque
potassium voltage-gated channel subfamily C member 1
Mouse
Rat
Dog
potassium voltage-gated channel subfamily C member 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P48547-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Gene Ontology Terms (32)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (280)
1 – 10 of 280
KCNC4
Tclin
Family: IC
Novelty: 0.01215128
p_int: 1
Score: 0.352
Data Source: BioPlex,STRINGDB
KCNAB1
Tbio
Family: IC
Novelty: 0.01413705
Score: 0.964
Data Source: STRINGDB
KCNAB2
Tbio
Family: IC
Novelty: 0.01752175
Score: 0.963
Data Source: STRINGDB
KCNAB3
Tbio
Family: IC
Novelty: 0.10128237
Score: 0.953
Data Source: STRINGDB
KCNIP1
Tbio
Family: IC
Novelty: 0.01790042
Score: 0.901
Data Source: STRINGDB
KCNIP2
Tbio
Family: IC
Novelty: 0.01123517
Score: 0.885
Data Source: STRINGDB
DPP6
Tbio
Family: Enzyme
Novelty: 0.00435138
Score: 0.872
Data Source: STRINGDB
DPP10
Tbio
Family: Enzyme
Novelty: 0.02313473
Score: 0.836
Data Source: STRINGDB
KCNIP3
Tbio
Family: IC
Novelty: 0.01371555
Score: 0.807
Data Source: STRINGDB
FAU
Tbio
Novelty: 0.01170009
Score: 0.788
Data Source: STRINGDB
Publication Statistics
PubMed Score  380.71

PubMed score by year
PubTator Score  136.75

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer