Tclin KCNC1 Potassium voltage-gated channel subfamily C member 1

Protein Summary

Description

Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient (PubMed:25401298). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons. This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both "b" and "alpha", while the shorter isoform has been called both "a" and "beta" (PMIDs 1432046, 12091563). [provided by RefSeq, Oct 2014]

Uniprot Accession IDs

• P48547
• K4DI87

Gene Name

• KCNC1

Ensembl ID

• ENST00000265969
• ENSP00000265969
• ENSG00000129159
• ENST00000379472
• ENSP00000368785

Symbol

• KV4
• EPM7
• NGK2
• KV3.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.88
cellular component	0.76
gene perturbation	0.74
transcription factor perturbation	0.68

Protein Classes

DTO Classes

Protein / Ion Channel / Potassium Channel Family / C (Shaw) Subfamily / Kv3.1/kcnc1 Sub-subfamily / Potassium Voltage-gated Channel Subfamily C Member 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 418.32   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 381   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 418.32   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 381   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8