GIPR
Gastric inhibitory polypeptide receptor
Protein Summary
This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]
- ENST00000263281
- ENSP00000263281
- ENSG00000010310
- ENST00000304207
- ENSP00000305321
- ENST00000590918
- ENSP00000467494
- PGQTL2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.9 | ||
protein domain | 0.73 | ||
cell type or tissue | 0.64 | ||
biological term | 0.58 | ||
gene perturbation | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 159.39 (req: < 5)
Gene RIFs: 56 (req: <= 3)
Antibodies: 567 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 159.39 (req: >= 5)
Gene RIFs: 56 (req: > 3)
Antibodies: 567 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 35
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1