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Tchem
GIPR
Gastric inhibitory polypeptide receptor

Protein Summary
Description
This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263281
  • ENSP00000263281
  • ENSG00000010310
  • ENST00000304207
  • ENSP00000305321
  • ENST00000590918
  • ENSP00000467494

Symbol
  • PGQTL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.9
protein domain
0.73
cell type or tissue
0.64
biological term
0.58
gene perturbation
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.36   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 567   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.36   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 567   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
12
5
15
4.2
99.6
glucose tolerance test
4
2
4
94.6
visceral adipose tissue measurement
1
1
1
93.8
waist-hip ratio
2
1
2
93.2
glucose-dependent insulinotropic peptide measurement
2
1
2
77.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
15
4.2
99.6
glucose tolerance test
4
94.6
visceral adipose tissue measurement
1
93.8
waist-hip ratio
2
93.2
glucose-dependent insulinotropic peptide measurement
2
77.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
gastric inhibitory polypeptide receptor
716192
Mouse
MGI:1352753
381853
Rat
RGD:2689
25024
Dog
gastric inhibitory polypeptide receptor
VGNC:41228
484439
Horse
gastric inhibitory polypeptide receptor
VGNC:18345
100070901
Species
Name
OMA
EggNOG
Inparanoid
Macaque
gastric inhibitory polypeptide receptor
Mouse
Rat
Dog
gastric inhibitory polypeptide receptor
Horse
gastric inhibitory polypeptide receptor
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P48546-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Glucagon-type ligand receptors
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Glucagon-type ligand receptors
Gene Ontology Terms (21)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (174)
1 – 10 of 174
GIP
Tchem
Novelty: 0.0007219
Score: 0.997
Data Source: Reactome,STRINGDB
GCG
Tchem
Novelty: 0.00004879
Score: 0.978
Data Source: STRINGDB
ADCY5
Tchem
Family: Enzyme
Novelty: 0.00307839
Score: 0.971
Data Source: STRINGDB
MC4R
Tclin
Family: GPCR
Novelty: 0.00091593
Score: 0.95
Data Source: STRINGDB
SCT
Tbio
Novelty: 0.00070278
Score: 0.949
Data Source: STRINGDB
CRH
Tbio
Novelty: 0.000147
Score: 0.947
Data Source: STRINGDB
HTR4
Tclin
Family: GPCR
Novelty: 0.00951779
Score: 0.944
Data Source: STRINGDB
GPR45
Tbio
Family: GPCR
Novelty: 0.08366919
Score: 0.942
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002436
Score: 0.942
Data Source: STRINGDB
MC2R
Tclin
Family: GPCR
Novelty: 0.00485539
Score: 0.942
Data Source: STRINGDB
Publication Statistics
PubMed Score  136.36

PubMed score by year
PubTator Score  57.63

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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