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Tbio
PCP4
Calmodulin regulator protein PCP4

Protein Summary
Description
Functions as a modulator of calcium-binding by calmodulin. Thereby, regulates calmodulin activity and the different processes it controls (PubMed:19106096, PubMed:23204517, PubMed:27876793). For instance, may play a role in neuronal differentiation through activation of calmodulin-dependent kinase signaling pathways (PubMed:21491429).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328619
  • ENSP00000329403
  • ENSG00000183036

Symbol
  • PEP19
  • PEP-19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
tissue
0.71
transcription factor perturbation
0.68
small molecule perturbation
0.67
kinase perturbation
0.66


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.13   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.13   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Purkinje cell protein 4
VGNC:1135
474001
Mouse
MGI:97509
18546
Rat
RGD:3271
25510
Dog
Purkinje cell protein 4
VGNC:44319
610723
Horse
Purkinje cell protein 4
VGNC:21214
102149269
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Purkinje cell protein 4
Mouse
Rat
Dog
Purkinje cell protein 4
Horse
Purkinje cell protein 4
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P48539-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (41)
1 – 10 of 41
SH3BGRL3
Tbio
Novelty:  0.08079434
p_int:  0.999990712
p_ni:  0.000009252
p_wrong:  3.6e-8
Data Source:  BioPlex
UBL3
Tbio
Novelty:  0.12397801
p_int:  0.99958782
p_ni:  0.000411435
p_wrong:  7.45e-7
Data Source:  BioPlex
RAB27A
Tchem
Family:  Enzyme
Novelty:  0.00369416
p_int:  0.997915988
p_ni:  0.002084008
p_wrong:  4e-9
Data Source:  BioPlex
BCAS2
Tbio
Novelty:  0.05425016
p_int:  0.995822002
p_ni:  0.004176952
p_wrong:  0.000001046
Data Source:  BioPlex
TUSC2
Tbio
Novelty:  0.05958876
p_int:  0.989932089
p_ni:  0.003971903
p_wrong:  0.006096008
Data Source:  BioPlex
ABCG1
Tbio
Family:  Transporter
Novelty:  0.00213282
Score:  0.71
Data Source:  STRINGDB
SIM2
Tbio
Novelty:  0.00773416
Score:  0.701
Data Source:  STRINGDB
NRGN
Tbio
Novelty:  0.00352757
Score:  0.666
Data Source:  STRINGDB
ETS2
Tbio
Family:  TF
Novelty:  0.00327214
Score:  0.641
Data Source:  STRINGDB
GAP43
Tbio
Novelty:  0.00091023
Score:  0.583
Data Source:  STRINGDB
Publication Statistics
PubMed Score  117.13

PubMed score by year
PubTator Score  34.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer