Pharos: Illuminating the Druggable Genome

Tbio

Protein Summary

Description

Essential for the proper assembly of the glomerular and tubular basement membranes in kidney. (Microbial infection) Plays a role in human papillomavirus 16/HPV-16 endocytosis upon binding to cell surface receptor. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein ...more

Uniprot Accession IDs

Gene Name

CD151

Ensembl ID

ENST00000322008
ENSP00000324101
ENSG00000177697
ENST00000397420
ENSP00000380565
ENST00000397421
ENSP00000380566
ENST00000530726
ENSP00000432385

Symbol

TSPAN24
GP27
MER2
RAPH
SFA1
PETA-3
TSPAN24

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.88

tissue	0.78

PubMedID	0.76

biological term	0.75

disease	0.71

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 266.94 (req: < 5)

View Publications

Gene RIFs: 103 (req: <= 3)

View Gene RIFs

Antibodies: 607 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 266.94 (req: >= 5)

Gene RIFs: 103 (req: > 3)

Antibodies: 607 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (8)

Reactome (6)

PathwayCommons (1)

WikiPathways (1)

Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Assembly of collagen fibrils and other multimeric structures	57 targets	R-HSA-2022090

Reactome	Cell junction organization	88 targets	R-HSA-446728

Reactome	Cell-Cell communication	121 targets	R-HSA-1500931

Reactome	Collagen formation	90 targets	R-HSA-1474290

Reactome	Extracellular matrix organization	297 targets	R-HSA-1474244

Name	Explore in Pharos	Explore in Source
Assembly of collagen fibrils and other multimeric structures	57 targets	R-HSA-2022090

Cell junction organization	88 targets	R-HSA-446728

Cell-Cell communication	121 targets	R-HSA-1500931

Collagen formation	90 targets	R-HSA-1474290

Extracellular matrix organization	297 targets	R-HSA-1474244

Gene Ontology Terms (15)

Functions (1)

Components (7)

Processes (7)

Items per page:

1 – 1 of 1

GO Term	Evidence	Assigned by
integrin binding	Inferred from Direct Assay (IDA)	UniProtKB

Protein-Protein Interactions (75)

1 – 10 of 75

See Interactions on String-DB

ITGA6

Tbio

Novelty: 0.00351957

p_int: 0.999922571

p_ni: 0.000077377

p_wrong: 5.3e-8

Score: 0.966

Data Source: BioPlex,Reactome,STRINGDB

ITGB2

Tclin

Novelty: 0.00237551

p_int: 0.998628095

p_ni: 0.00079667

p_wrong: 0.000575236

Data Source: BioPlex

LRRC52

Tbio

Family: IC

Novelty: 0.4058938

p_int: 0.895421423

p_ni: 0.007220608

p_wrong: 0.097357969

Data Source: BioPlex

TMPRSS11B

Tdark

Family: Enzyme

Novelty: 1.71428571

p_int: 0.891104397

p_ni: 0.002720751

p_wrong: 0.106174853

Data Source: BioPlex

NCEH1

Tchem

Family: Enzyme

Novelty: 0.02418747

p_int: 0.875548091

p_ni: 0.001198995

p_wrong: 0.123252914

Score: 0.188

Data Source: BioPlex,STRINGDB

ITGB4

Tbio

Novelty: 0.00494012

Score: 0.964