Tbio GCLM Glutamate--cysteine ligase regulatory subunit

Protein Summary

Description

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Uniprot Accession IDs

• P48507
• A8K334
• D3DT45
• M5A959
• Q6FHC1
• Q9NPX9
• Q9NU74

Gene Name

• GCLM

Ensembl ID

• ENST00000370238
• ENSP00000359258
• ENSG00000023909
• ENST00000615724
• ENSP00000484507

Symbol

• GLCLR
• GLCLR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
transcription factor binding site profile	0.93
chemical	0.89
disease	0.82
PubMedID	0.8

Protein Classes

PANTHER Classes

Protein / Ligase / Glutamate--cysteine Ligase Regulatory Subunit

DTO Classes

Protein / Enzyme / Ligase / Glutamate--cysteine Ligase Regulatory Subunit

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 317.09   (req: < 5)

Gene RIFs: 43   (req: <= 3)

Antibodies: 394   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 317.09   (req: >= 5)

Gene RIFs: 43   (req: > 3)

Antibodies: 394   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0