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Tbio
PPP3CC
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

Protein Summary
Description
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000240139
  • ENSP00000240139
  • ENSG00000120910
  • ENST00000289963
  • ENSP00000289963
  • ENST00000397775
  • ENSP00000380878

Symbol
  • CALNA3
  • CNA3
  • CNA3
  • CALNA3
  • PP2Bgamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
disease perturbation
0.95
virus perturbation
0.95
kinase perturbation
0.81
PubMedID
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.5   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.5   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (67)
Activation of BAD and translocation to mitochondria (R-HSA-111447)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of BAD and translocation to mitochondria
Reactome
Activation of BH3-only proteins
Reactome
Apoptosis
Reactome
DARPP-32 events
Reactome
G alpha (i) signalling events
Name
Explore in Pharos
Explore in Source
Activation of BAD and translocation to mitochondria
Activation of BH3-only proteins
Apoptosis
DARPP-32 events
G alpha (i) signalling events
Protein-Protein Interactions (211)
1 – 10 of 211
NFATC1
Tbio
Family: TF
Novelty: 0.0015406
p_int: 1
Score: 0.984
Data Source: BioPlex,STRINGDB
RCAN3
Tbio
Novelty: 0.16735029
p_int: 1
Score: 0.851
Data Source: BioPlex,STRINGDB
RCAN1
Tbio
Novelty: 0.00396344
p_int: 1
Score: 0.827
Data Source: BioPlex,STRINGDB
SIK3
Tchem
Family: Kinase
Novelty: 0.04907412
p_int: 0.999999999
p_ni: 1e-9
Score: 0.248
Data Source: BioPlex,STRINGDB
NFATC4
Tbio
Family: TF
Novelty: 0.01037729
p_int: 0.999999989
p_ni: 4e-9
p_wrong: 7e-9
Score: 0.717
Data Source: BioPlex,STRINGDB
TMEM200A
Tbio
Novelty: 0.03088008
p_int: 0.999999768
p_ni: 2.32e-7
Score: 0.638
Data Source: BioPlex,STRINGDB
TNS4
Tbio
Novelty: 0.05243227
p_int: 0.999997259
p_ni: 0.000002741
p_wrong: 1e-9
Data Source: BioPlex
PPP3R2
Tbio
Novelty: 0.0210854
p_int: 0.999990812
p_ni: 0.000007885
p_wrong: 0.000001304
Score: 0.971
Data Source: BioPlex,STRINGDB
RCAN2
Tbio
Novelty: 0.00795081
p_int: 0.99998547
p_ni: 0.00001453
Score: 0.835
Data Source: BioPlex,STRINGDB
DEFA1
Tbio
Novelty: 0.01616437
p_int: 0.999982868
p_ni: 0.000017132
Data Source: BioPlex
Publication Statistics
PubMed Score  25.50

PubMed score by year
PubTator Score  20.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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