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Tbio
PPP3CC
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

Protein Summary
Description
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000240139
  • ENSP00000240139
  • ENSG00000120910
  • ENST00000289963
  • ENSP00000289963
  • ENST00000397775
  • ENSP00000380878

Symbol
  • CALNA3
  • CNA3
  • CNA3
  • CALNA3
  • PP2Bgamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
disease perturbation
0.95
virus perturbation
0.95
kinase perturbation
0.81
PubMedID
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.17   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.17   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (211)
NFATC1
Tchem
Family:  TF
Novelty:  0.00130337
p_int:  1
Score:  0.984
Data Source:  BioPlex,STRINGDB
RCAN3
Tbio
Novelty:  0.12819457
p_int:  1
Score:  0.851
Data Source:  BioPlex,STRINGDB
RCAN1
Tbio
Novelty:  0.0030009
p_int:  1
Score:  0.827
Data Source:  BioPlex,STRINGDB
SIK3
Tchem
Family:  Kinase
Novelty:  0.02936655
p_int:  0.999999999
p_ni:  1e-9
Score:  0.248
Data Source:  BioPlex,STRINGDB
NFATC4
Tbio
Family:  TF
Novelty:  0.00788306
p_int:  0.999999989
p_ni:  4e-9
p_wrong:  7e-9
Score:  0.717
Data Source:  BioPlex,STRINGDB
TMEM200A
Tdark
Novelty:  0.25580793
p_int:  0.999999768
p_ni:  2.32e-7
Score:  0.638
Data Source:  BioPlex,STRINGDB
TNS4
Tbio
Novelty:  0.048713
p_int:  0.999997259
p_ni:  0.000002741
p_wrong:  1e-9
Data Source:  BioPlex
PPP3R2
Tbio
Novelty:  0.01121867
p_int:  0.999990812
p_ni:  0.000007885
p_wrong:  0.000001304
Score:  0.971
Data Source:  BioPlex,STRINGDB
RCAN2
Tbio
Novelty:  0.00174006
p_int:  0.99998547
p_ni:  0.00001453
Score:  0.835
Data Source:  BioPlex,STRINGDB
DEFA1
Tbio
Novelty:  0.01027492
p_int:  0.999982868
p_ni:  0.000017132
Data Source:  BioPlex
Nearest Tclin Targets (8)
Explore Nearest Tclin Targets
Pathways (67)
Activation of BAD and translocation to mitochondria (R-HSA-111447)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of BAD and translocation to mitochondria
Reactome
Activation of BH3-only proteins
Reactome
Apoptosis
Reactome
DARPP-32 events
Reactome
G alpha (i) signalling events
Name
Explore in Pharos
Explore in Source
Activation of BAD and translocation to mitochondria
Activation of BH3-only proteins
Apoptosis
DARPP-32 events
G alpha (i) signalling events
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
73.9
platelet crit
1
1
1
73
glomerular filtration rate
2
2
2
70.4
creatinine measurement
1
1
1
58.4
2
2
2
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
73.9
platelet crit
1
73
glomerular filtration rate
2
70.4
creatinine measurement
1
58.4
2
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 3 catalytic subunit gamma
VGNC:7598
742406
Macaque
protein phosphatase 3 catalytic subunit gamma
708233
Mouse
MGI:107162
19057
Dog
protein phosphatase 3 catalytic subunit gamma
VGNC:44920
609027
Horse
protein phosphatase 3 catalytic subunit gamma
VGNC:21787
100057357
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 3 catalytic subunit gamma
Macaque
protein phosphatase 3 catalytic subunit gamma
Mouse
Dog
protein phosphatase 3 catalytic subunit gamma
Horse
protein phosphatase 3 catalytic subunit gamma
Publication Statistics
PubMed Score 37.17
PubMed score by year
PubTator Score 20.46
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title