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Tbio
ALDH3B2
Aldehyde dehydrogenase family 3 member B2

Protein Summary
Description
Oxidizes medium and long chain aldehydes into non-toxic fatty acids. This gene encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The gene of this particular family member is over 10 kb in length. Altered methylation patterns at this locus have been observed in spermatozoa derived from patients exhibiting reduced fecundity. [provided by RefSeq, Aug 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349015
  • ENSP00000255084
  • ENSG00000132746
  • ENST00000530069
  • ENSP00000431595

Symbol
  • ALDH8
  • ALDH8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
cell type or tissue
0.68
pathway
0.67
cell line
0.62
microRNA
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.08   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.08   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
ALDH3B1
Tbio
Family:  Enzyme
Novelty:  0.03330389
p_int:  0.999999534
p_ni:  4.66e-7
Score:  0.591
Data Source:  BioPlex,STRINGDB
CYP2E1
Tchem
Novelty:  0.00030504
Score:  0.954
Data Source:  STRINGDB
AKR1A1
Tchem
Family:  Enzyme
Novelty:  0.0054436
Score:  0.943
Data Source:  STRINGDB
ACSS1
Tbio
Family:  Enzyme
Novelty:  0.02003886
Score:  0.938
Data Source:  STRINGDB
ACSS2
Tchem
Family:  Enzyme
Novelty:  0.00448879
Score:  0.934
Data Source:  STRINGDB
CARNS1
Tbio
Family:  Enzyme
Novelty:  0.09322055
Score:  0.934
Data Source:  STRINGDB
DERA
Tbio
Family:  Enzyme
Novelty:  0.0079635
Score:  0.932
Data Source:  STRINGDB
MAOA
Tclin
Family:  Enzyme
Novelty:  0.00031037
Score:  0.931
Data Source:  STRINGDB
ABAT
Tclin
Family:  Enzyme
Novelty:  0.0078359
Score:  0.928
Data Source:  STRINGDB
COMT
Tclin
Family:  Enzyme
Novelty:  0.00025107
Score:  0.928
Data Source:  STRINGDB
Nearest Tclin Targets (13)
Explore Nearest Tclin Targets
Pathways (23)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
2
4
6
91.8
BMI-adjusted hip circumference
2
4
4
85.2
urinary metabolite measurement
1
1
1
51.4
BMI-adjusted waist-hip ratio
1
1
1
21.5
serum metabolite measurement
1
1
1
21.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
6
91.8
BMI-adjusted hip circumference
4
85.2
urinary metabolite measurement
1
51.4
BMI-adjusted waist-hip ratio
1
21.5
serum metabolite measurement
1
21.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aldehyde dehydrogenase 3 family member B2
VGNC:3225
466685
Macaque
aldehyde dehydrogenase 3 family member B2
721683
Mouse
MGI:1914939
67689
Cow
aldehyde dehydrogenase family 3 member B1-like
508879
Pig
aldehyde dehydrogenase family 3 member B2-like
100522421
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aldehyde dehydrogenase 3 family member B2
Macaque
aldehyde dehydrogenase 3 family member B2
Mouse
Cow
aldehyde dehydrogenase family 3 member B1-like
Pig
aldehyde dehydrogenase family 3 member B2-like
Publication Statistics
PubMed Score 11.08
PubMed score by year
PubTator Score 5.45
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title