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Tbio
ARCN1
Coatomer subunit delta

Protein Summary
Description
Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). This gene maps in a region, which include the mixed lineage leukemia and Friend leukemia virus integration 1 genes, where multiple disease-associated chromosome translocations occur. It is an intracellular protein. Archain sequences are well conserved among eukaryotes and this prote ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264028
  • ENSP00000264028
  • ENSG00000095139
  • ENST00000392859
  • ENSP00000376599

Symbol
  • COPD
  • COPD
  • SRMMD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
interacting protein
0.92
virus perturbation
0.88
microRNA
0.85
kinase perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.54   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.54   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
1
1
29.1
monocyte percentage of leukocytes
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
29.1
monocyte percentage of leukocytes
1
29
Pathways (12)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Golgi-to-ER retrograde transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
ER to Golgi Anterograde Transport
Golgi-to-ER retrograde transport
Gene Ontology Terms (15)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (257)
1 – 10 of 257
COPG1
Tbio
Novelty: 0.01331193
p_int: 0.99910116
p_ni: 0.00089884
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
COPZ1
Tbio
Novelty: 0.01405958
p_int: 0.989293197
p_ni: 0.010706803
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
COPB1
Tbio
Novelty: 0.0078407
Score: 0.999
Data Source: Reactome,STRINGDB
COPB2
Tbio
Novelty: 0.02705751
Score: 0.999
Data Source: Reactome,STRINGDB
COPE
Tbio
Novelty: 0.02037359
Score: 0.999
Data Source: Reactome,STRINGDB
COPA
Tbio
Novelty: 0.02712824
Score: 0.999
Data Source: Reactome,STRINGDB
COPG2
Tbio
Novelty: 0.06126837
Score: 0.995
Data Source: Reactome,STRINGDB
COPZ2
Tdark
Novelty: 0.21561497
Score: 0.994
Data Source: Reactome,STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.982
Data Source: STRINGDB
RINT1
Tbio
Novelty: 0.04546291
Score: 0.963
Data Source: STRINGDB
Publication Statistics
PubMed Score  14.54

PubMed score by year
PubTator Score  10.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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