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Tclin
RXRG
Retinoic acid receptor RXR-gamma

Protein Summary
Description
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359842
  • ENSP00000352900
  • ENSG00000143171

Symbol
  • NR2B3
  • RXRC
  • NR2B3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
gene perturbation
0.97
molecular function
0.94
protein domain
0.92
biological process
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.37   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 368   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.37   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 368   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 60
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (87)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Nuclear Receptor transcription pathway
Reactome
RNA Polymerase II Transcription
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Nuclear Receptor transcription pathway
RNA Polymerase II Transcription
Signal Transduction
Gene Ontology Terms (8)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (73)
1 – 10 of 73
NR1H2
Tchem
Family: NR
Novelty: 0.01410936
p_int: 1
Score: 0.992
Data Source: BioPlex,STRINGDB
RXRA
Tclin
Family: NR
Novelty: 0.00314166
p_int: 1
Score: 0.967
Data Source: BioPlex,STRINGDB
NR2F6
Tbio
Family: NR
Novelty: 0.02380073
p_int: 0.933227549
p_ni: 0.004492189
p_wrong: 0.062280262
Score: 0.29
Data Source: BioPlex,STRINGDB
RARA
Tclin
Family: NR
Novelty: 0.00083219
Score: 0.985
Data Source: STRINGDB
PPARG
Tclin
Family: NR
Novelty: 0.00012454
Score: 0.983
Data Source: STRINGDB
RARG
Tclin
Family: NR
Novelty: 0.00656363
Score: 0.982
Data Source: Reactome,STRINGDB
NR1H3
Tchem
Family: NR
Novelty: 0.00605052
Score: 0.982
Data Source: STRINGDB
NCOR2
Tchem
Family: TF
Novelty: 0.00127046
Score: 0.981
Data Source: STRINGDB
RARB
Tclin
Family: NR
Novelty: 0.00294192
Score: 0.977
Data Source: STRINGDB
THRB
Tclin
Family: NR
Novelty: 0.0014337
Score: 0.97
Data Source: STRINGDB
Publication Statistics
PubMed Score  46.37

PubMed score by year
PubTator Score  25.35

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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