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Tclin
RXRG
Retinoic acid receptor RXR-gamma

Protein Summary
Description
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359842
  • ENSP00000352900
  • ENSG00000143171

Symbol
  • NR2B3
  • RXRC
  • NR2B3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
gene perturbation
0.97
molecular function
0.94
protein domain
0.92
biological process
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.12   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 368   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.12   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 368   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 68
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menarche
3
2
2
4.2
88
BMI-adjusted hip circumference
1
2
2
64.2
BMI-adjusted waist circumference
2
2
2
49.2
BMI-adjusted waist-hip ratio
1
1
1
46.5
mathematical ability
2
2
2
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menarche
2
4.2
88
BMI-adjusted hip circumference
2
64.2
BMI-adjusted waist circumference
2
49.2
BMI-adjusted waist-hip ratio
1
46.5
mathematical ability
2
24.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
retinoid X receptor gamma
VGNC:1534
457476
Macaque
retinoid X receptor gamma
694807
Mouse
MGI:98216
20183
Rat
RGD:620046
83574
Dog
retinoid X receptor gamma
VGNC:45819
478989
Species
Name
OMA
EggNOG
Inparanoid
Chimp
retinoid X receptor gamma
Macaque
retinoid X receptor gamma
Mouse
Rat
Dog
retinoid X receptor gamma
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P48443-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (87)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Nuclear Receptor transcription pathway
Reactome
RNA Polymerase II Transcription
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Nuclear Receptor transcription pathway
RNA Polymerase II Transcription
Signal Transduction
Gene Ontology Terms (8)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (73)
1 – 10 of 73
NR1H2
Tchem
Family:  NR
Novelty:  0.01296966
p_int:  1
Score:  0.992
Data Source:  BioPlex,STRINGDB
RXRA
Tclin
Family:  NR
Novelty:  0.00244343
p_int:  1
Score:  0.967
Data Source:  BioPlex,STRINGDB
NR2F6
Tbio
Family:  NR
Novelty:  0.02314124
p_int:  0.933227549
p_ni:  0.004492189
p_wrong:  0.062280262
Score:  0.29
Data Source:  BioPlex,STRINGDB
RARA
Tclin
Family:  NR
Novelty:  0.00080574
Score:  0.985
Data Source:  STRINGDB
PPARG
Tclin
Family:  NR
Novelty:  0.00010033
Score:  0.983
Data Source:  STRINGDB
RARG
Tclin
Family:  NR
Novelty:  0.00667159
Score:  0.982
Data Source:  Reactome,STRINGDB
NR1H3
Tchem
Family:  NR
Novelty:  0.00394862
Score:  0.982
Data Source:  STRINGDB
NCOR2
Tchem
Family:  TF
Novelty:  0.00066449
Score:  0.981
Data Source:  STRINGDB
RARB
Tclin
Family:  NR
Novelty:  0.00257427
Score:  0.977
Data Source:  STRINGDB
THRB
Tclin
Family:  NR
Novelty:  0.0014797
Score:  0.97
Data Source:  STRINGDB
Publication Statistics
PubMed Score  61.12

PubMed score by year
PubTator Score  25.35

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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