Tbio SOX9 Transcription factor SOX-9

Protein Summary

Description

Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development (PubMed:24038782). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219 (By similarity). The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P48436
• Q53Y80

Gene Name

• SOX9

Ensembl ID

• ENST00000245479
• ENSP00000245479
• ENSG00000125398
• ENST00000645356
• ENSP00000495527

Symbol

• CMD1
• SRA1
• CMPD1
• SRXX2
• SRXY10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	1
PubMedID	0.99
small molecule perturbation	0.94
gene perturbation	0.9

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2712.05   (req: < 5)

Gene RIFs: 477   (req: <= 3)

Antibodies: 795   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2712.05   (req: >= 5)

Gene RIFs: 477   (req: > 3)

Antibodies: 795   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 131

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0