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Tbio
SOX2
Transcription factor SOX-2

Protein Summary
Description
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325404
  • ENSP00000323588
  • ENSG00000181449

Symbol
  • ANOP3
  • MCOPS3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
gene perturbation
0.92
PubMedID
0.88
molecular function
0.81
phenotype
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2824.55   (req: < 5)
Gene RIFs: 490   (req: <= 3)
Antibodies: 1595   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2824.55   (req: >= 5)
Gene RIFs: 490   (req: > 3)
Antibodies: 1595   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (555)
1 – 10 of 555
SOX21
Tbio
Family:  TF
Novelty:  0.01692118
p_int:  1
Score:  0.695
Data Source:  BioPlex,STRINGDB
SOX14
Tbio
Family:  TF
Novelty:  0.04081868
p_int:  1
Score:  0.475
Data Source:  BioPlex,STRINGDB
RBP1
Tbio
Novelty:  0.00199929
p_int:  0.997151973
p_ni:  0.002840178
p_wrong:  0.000007849
Score:  0.444
Data Source:  BioPlex,STRINGDB
PLPBP
Tbio
Family:  Enzyme
Novelty:  0.04352366
p_int:  0.996418182
p_ni:  0.000839887
p_wrong:  0.00274193
Score:  0.189
Data Source:  BioPlex,STRINGDB
FAHD2A
Tdark
Family:  Enzyme
Novelty:  0.68981789
p_int:  0.990797849
p_ni:  0.009202146
p_wrong:  5e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
PRTFDC1
Tbio
Family:  Enzyme
Novelty:  0.13607881
p_int:  0.985019062
p_ni:  0.004077268
p_wrong:  0.01090367
Score:  0.201
Data Source:  BioPlex,STRINGDB
SERPINB1
Tbio
Family:  Enzyme
Novelty:  0.00267786
p_int:  0.984018306
p_ni:  0.015981694
Score:  0.201
Data Source:  BioPlex,STRINGDB
ENPP4
Tbio
Family:  Enzyme
Novelty:  0.09897251
p_int:  0.978190109
p_ni:  0.000146229
p_wrong:  0.021663661
Score:  0.163
Data Source:  BioPlex,STRINGDB
OXSM
Tbio
Family:  Enzyme
Novelty:  0.00615894
p_int:  0.963482236
p_ni:  0.036480067
p_wrong:  0.000037697
Score:  0.197
Data Source:  BioPlex,STRINGDB
PAK2
Tchem
Family:  Kinase
Novelty:  0.0149123
p_int:  0.950063292
p_ni:  0.049936698
p_wrong:  9e-9
Score:  0.191
Data Source:  BioPlex,STRINGDB
Pathways (29)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Deactivation of the beta-catenin transactivating complex
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Deactivation of the beta-catenin transactivating complex
Developmental Biology
Gene expression (Transcription)
Generic Transcription Pathway
Gene Ontology Terms (44)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
synophrys measurement
1
1
1
80.3
corneal topography
2
1
2
79.9
puberty onset measurement
3
1
3
79.1
risk-taking behaviour
3
3
4
1
72.3
smoking status measurement
2
2
2
68.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
synophrys measurement
1
80.3
corneal topography
2
79.9
puberty onset measurement
3
79.1
risk-taking behaviour
4
1
72.3
smoking status measurement
2
68.5
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:98364
20674
Rat
RGD:1565646
499593
Dog
SRY-box 2
VGNC:46678
488092
Horse
SRY-box 2
VGNC:23460
100146979
Cow
SRY-box 2
VGNC:35146
784383
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
SRY-box 2
Horse
SRY-box 2
Cow
SRY-box 2
Publication Statistics
PubMed Score 2824.55
PubMed score by year
PubTator Score 1381.52
PubTator score by year