Tbio SOX2 Transcription factor SOX-2

Protein Summary

Description

Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P48431
• Q14537

Gene Name

• SOX2

Ensembl ID

• ENST00000325404
• ENSP00000323588
• ENSG00000181449

Symbol

• ANOP3
• MCOPS3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
gene perturbation	0.92
PubMedID	0.88
molecular function	0.81
phenotype	0.76

Protein Classes

PANTHER Classes

Protein / ... / Hmg Box Transcription Factor / Transcription Factor Sox-2

DTO Classes

Protein / Transcription Factor / Hmg Box Transcription Factor / Transcription Factor Sox-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3227.34   (req: < 5)

Gene RIFs: 745   (req: <= 3)

Antibodies: 1595   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3227.34   (req: >= 5)

Gene RIFs: 745   (req: > 3)

Antibodies: 1595   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0