Tbio PIP4K2A Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

Protein Summary

Description

Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size. Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P48426
• B0YJ66
• B4DGX2
• D3DRV1
• P53807
• Q5VUX3

Gene Name

• PIP4K2A

Ensembl ID

• ENST00000376573
• ENSP00000365757
• ENSG00000150867
• ENST00000545335
• ENSP00000442098

Symbol

• PIP5K2
• PIP5K2A
• PIPK
• PI5P4KA
• PIP5K2A
• PIP5KIIA
• PIP5KII-alpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
molecular function	0.91
virus perturbation	0.9
interacting protein	0.8
disease perturbation	0.79

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Phosphatidylinositol 5-phosphate 4-kinase Type-2 Alpha

DTO Classes

Protein / Kinase / Non-protein Kinase / Lipid Kinase / Phosphatidylinositol 5-phosphate 4-kinase Type-2 Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.33   (req: < 5)

Gene RIFs: 43   (req: <= 3)

Antibodies: 327   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.33   (req: >= 5)

Gene RIFs: 43   (req: > 3)

Antibodies: 327   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0