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Tbio
PIP4K2A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

Protein Summary
Description
Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size. Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376573
  • ENSP00000365757
  • ENSG00000150867
  • ENST00000545335
  • ENSP00000442098

Symbol
  • PIP5K2
  • PIP5K2A
  • PIPK
  • PI5P4KA
  • PIP5K2A
  • PIP5KIIA
  • PIP5KII-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
molecular function
0.91
virus perturbation
0.9
interacting protein
0.8
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.66   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 327   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.66   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 327   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (205)
PIP4K2B
Tchem
Family:  Kinase
Novelty:  0.06261627
p_int:  1
Score:  0.962
Data Source:  BioPlex,Reactome,STRINGDB
DIP2C
Tbio
Novelty:  0.18897853
p_int:  0.999999989
p_ni:  8e-9
p_wrong:  3e-9
Score:  0.208
Data Source:  BioPlex,STRINGDB
ZRANB2
Tbio
Novelty:  0.06105086
p_int:  0.999999977
p_ni:  2.3e-8
Score:  0.696
Data Source:  BioPlex,STRINGDB
UBTF
Tbio
Family:  TF
Novelty:  0.00421069
p_int:  0.999999963
p_ni:  3.7e-8
Score:  0.162
Data Source:  BioPlex,STRINGDB
AFF3
Tbio
Family:  TF
Novelty:  0.02276155
p_int:  0.999999958
p_ni:  3.9e-8
p_wrong:  3e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
RTF1
Tbio
Family:  Enzyme
Novelty:  0.02255644
p_int:  0.999999839
p_ni:  2.1e-8
p_wrong:  1.4e-7
Data Source:  BioPlex
AFF4
Tbio
Family:  TF
Novelty:  0.02113896
p_int:  0.999999818
p_ni:  1.81e-7
p_wrong:  1e-9
Score:  0.232
Data Source:  BioPlex,STRINGDB
BRD3
Tchem
Family:  Epigenetic
Novelty:  0.00335409
p_int:  0.999999709
p_ni:  2.88e-7
p_wrong:  4e-9
Score:  0.274
Data Source:  BioPlex,STRINGDB
MLLT3
Tchem
Novelty:  0.00361056
p_int:  0.999999679
p_ni:  3.21e-7
Score:  0.184
Data Source:  BioPlex,STRINGDB
PIP4K2C
Tchem
Family:  Kinase
Novelty:  0.11466436
p_int:  0.999999665
p_ni:  3.35e-7
p_wrong:  1e-9
Score:  0.934
Data Source:  BioPlex,Reactome,STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
Pathways (29)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Intracellular signaling by second messengers
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Intracellular signaling by second messengers
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.3
75.7
1
1
0
1.4
72.6
body height
1
1
1
59.9
lymphocyte percentage of leukocytes
1
1
1
36.5
serum non-albumin protein measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
75.7
0
1.4
72.6
body height
1
59.9
lymphocyte percentage of leukocytes
1
36.5
serum non-albumin protein measurement
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
VGNC:12426
742458
Macaque
phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
710724
Mouse
MGI:1298206
18718
Dog
phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
608414
Horse
phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
VGNC:21462
100066733
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
Macaque
phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
Mouse
Dog
phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
Horse
phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
Publication Statistics
PubMed Score 96.66
PubMed score by year
PubTator Score 38.58
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
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PMID
Year
Title