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Tclin
LEPR
Leptin receptor

Protein Summary
Description
Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity) (PubMed:9537324). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:25060689, PubMed:12504075, PubMed:8805376). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344610
  • ENSP00000340884
  • ENSG00000116678
  • ENST00000349533
  • ENSP00000330393
  • ENST00000371058
  • ENSP00000360097
  • ENST00000371059
  • ENSP00000360098
  • ENST00000371060
  • ENSP00000360099
  • ENST00000616738
  • ENSP00000483390

Symbol
  • DB
  • OBR
  • OBR
  • OB-R
  • CD295
  • LEP-R
  • LEPRD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.93
protein domain
0.92
trait
0.75
transcription factor binding site profile
0.75
PubMedID
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1091.02   (req: < 5)
Gene RIFs: 471   (req: <= 3)
Antibodies: 834   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1091.02   (req: >= 5)
Gene RIFs: 471   (req: > 3)
Antibodies: 834   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (192)
LEP
Tbio
Novelty:  0.00005295
p_int:  0.99999993
p_ni:  7e-8
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
ATP6V0D1
Tbio
Family:  Enzyme
Novelty:  0.05146108
p_int:  0.999999698
p_ni:  2.69e-7
p_wrong:  3.4e-8
Score:  0.293
Data Source:  BioPlex,STRINGDB
FAM19A2
Tbio
Novelty:  0.28999346
p_int:  0.999963061
p_ni:  0.000036927
p_wrong:  1.3e-8
Data Source:  BioPlex
CDCP1
Tbio
Novelty:  0.01385067
p_int:  0.999920698
p_ni:  0.000079298
p_wrong:  4e-9
Score:  0.313
Data Source:  BioPlex,STRINGDB
FAM19A4
Tbio
Novelty:  0.04305684
p_int:  0.999885493
p_ni:  0.000114502
p_wrong:  5e-9
Data Source:  BioPlex
BTNL8
Tdark
Novelty:  0.40339869
p_int:  0.999476416
p_ni:  0.000227879
p_wrong:  0.000295705
Score:  0.197
Data Source:  BioPlex,STRINGDB
SCGB1D1
Tbio
Novelty:  0.04199997
p_int:  0.999442875
p_ni:  0.000139924
p_wrong:  0.000417201
Data Source:  BioPlex
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
Score:  0.99
Data Source:  Reactome,STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.99
Data Source:  Reactome,STRINGDB
SOCS3
Tbio
Novelty:  0.00106095
Score:  0.99
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (233)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by Leptin
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by Leptin
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (55)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
13
30
38
14.8
100
body mass index
11
3
17
98.2
fibrinogen measurement
4
4
4
92.7
neutrophil count
4
7
7
91.2
leukocyte count
3
6
6
89.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
38
14.8
100
body mass index
17
98.2
fibrinogen measurement
4
92.7
neutrophil count
7
91.2
leukocyte count
6
89.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leptin receptor
VGNC:1296
456919
Macaque
leptin receptor
574126
Mouse
MGI:104993
16847
Rat
RGD:3001
24536
Dog
leptin receptor
VGNC:42638
450207
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leptin receptor
Macaque
leptin receptor
Mouse
Rat
Dog
leptin receptor
Publication Statistics
PubMed Score 1091.02
PubMed score by year
PubTator Score 733.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title