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Tbio
TFPI2
Tissue factor pathway inhibitor 2

Protein Summary
Description
May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin. This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222543
  • ENSP00000222543
  • ENSG00000105825
  • ENST00000649730
  • ENSP00000498094

Symbol
  • PP5
  • REF1
  • TFPI-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
biological term
0.77
small molecule perturbation
0.77
PubMedID
0.73
cell type or tissue
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 276.73   (req: < 5)
Gene RIFs: 101   (req: <= 3)
Antibodies: 449   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 276.73   (req: >= 5)
Gene RIFs: 101   (req: > 3)
Antibodies: 449   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate variability measurement
3
2
6
75.9
heart rate response to recovery post exercise
5
2
5
57.6
heart rate
1
1
1
12.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate variability measurement
6
75.9
heart rate response to recovery post exercise
5
57.6
heart rate
1
12.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tissue factor pathway inhibitor 2
VGNC:4534
463540
Macaque
tissue factor pathway inhibitor 2
700850
Mouse
MGI:108543
21789
Rat
RGD:628629
286926
Dog
tissue factor pathway inhibitor 2
VGNC:47302
475230
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tissue factor pathway inhibitor 2
Macaque
tissue factor pathway inhibitor 2
Mouse
Rat
Dog
tissue factor pathway inhibitor 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P48307-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (78)
1 – 10 of 78
IFT88
Tbio
Novelty:  0.00727114
p_int:  0.999995054
p_ni:  0.000004946
Data Source:  BioPlex
IFT52
Tbio
Novelty:  0.04183122
p_int:  0.999983824
p_ni:  0.000016176
Data Source:  BioPlex
TTC30A
Tdark
Novelty:  1.41742212
p_int:  0.99991067
p_ni:  0.000089265
p_wrong:  6.4e-8
Data Source:  BioPlex
IFT81
Tbio
Novelty:  0.01610195
p_int:  0.999863473
p_ni:  0.000136527
Data Source:  BioPlex
IFT46
Tdark
Novelty:  0.11310911
p_int:  0.999856195
p_ni:  0.000143743
p_wrong:  6.2e-8
Data Source:  BioPlex
IFT22
Tbio
Family:  Enzyme
Novelty:  0.18342877
p_int:  0.999835809
p_ni:  0.000164191
Data Source:  BioPlex
IFT74
Tbio
Novelty:  0.07195266
p_int:  0.999797454
p_ni:  0.000202546
Data Source:  BioPlex
DCAF5
Tdark
Novelty:  0.39565074
p_int:  0.999676696
p_ni:  0.000323304
Data Source:  BioPlex
DSTYK
Tchem
Family:  Kinase
Novelty:  0.12049855
p_int:  0.999661738
p_ni:  0.000338262
Data Source:  BioPlex
AHCYL2
Tbio
Family:  Enzyme
Novelty:  0.08695339
p_int:  0.999339053
p_ni:  0.000660947
Data Source:  BioPlex
Publication Statistics
PubMed Score  276.73

PubMed score by year
PubTator Score  302.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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