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Tbio
REG1B
Lithostathine-1-beta

Protein Summary
Description
Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration. This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene encodes a protein secreted by the exocrine pancreas that is highly similar to the REG1A protein. The related REG1A protein is associated with islet cell regeneration and diabetogenesis, and may be involved in pancreatic lithogenesis. Reg family members REG1A, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305089
  • ENSP00000303206
  • ENSG00000172023

Symbol
  • PSPS2
  • REGL
  • REGH
  • REGL
  • PSPS2
  • REGI-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.78
protein domain
0.58
gene perturbation
0.47
tissue
0.46
metabolite
0.45


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.31   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.31   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
regenerating family member 1 beta
VGNC:10750
459347
Species
Name
OMA
EggNOG
Inparanoid
Chimp
regenerating family member 1 beta
Protein-Protein Interactions (19)
1 – 10 of 19
REG1A
Tbio
Novelty: 0.00492251
p_int: 0.999999992
p_wrong: 8e-9
Score: 0.93
Data Source: BioPlex,STRINGDB
ZC3H12A
Tbio
Family: Enzyme
Novelty: 0.00651373
Score: 0.761
Data Source: STRINGDB
REG3A
Tbio
Novelty: 0.00325832
Score: 0.686
Data Source: STRINGDB
CLEC1A
Tbio
Novelty: 0.13298999
Score: 0.643
Data Source: STRINGDB
DEFA6
Tbio
Novelty: 0.0363171
Score: 0.594
Data Source: STRINGDB
PTER
Tbio
Family: Enzyme
Novelty: 0.01347498
Score: 0.571
Data Source: STRINGDB
PAX2
Tbio
Family: TF
Novelty: 0.00160808
Score: 0.548
Data Source: STRINGDB
SYCN
Tbio
Novelty: 0.0354405
Score: 0.525
Data Source: STRINGDB
CUZD1
Tbio
Novelty: 0.06197067
Score: 0.504
Data Source: STRINGDB
DEFA5
Tbio
Novelty: 0.00863727
Score: 0.48
Data Source: STRINGDB
Publication Statistics
PubMed Score  43.31

PubMed score by year
PubTator Score  25.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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