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Tdark
ATP5MC3
ATP synthase F(0) complex subunit C3, mitochondrial

Protein Summary
Description
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element. This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284727
  • ENSP00000284727
  • ENSG00000154518
  • ENST00000392541
  • ENSP00000376324
  • ENST00000409194
  • ENSP00000387317

Symbol
  • ATP5G3
  • P3
  • ATP5G3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.28   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 39   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.28   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (196)
TMEM31
Tdark
Novelty:  0.65381391
p_int:  0.999079032
p_ni:  5.15e-7
p_wrong:  0.000920453
Data Source:  BioPlex
COL20A1
Tdark
Novelty:  0.39788946
p_int:  0.997904114
p_ni:  0.002000653
p_wrong:  0.000095233
Score:  0.205
Data Source:  BioPlex,STRINGDB
ATP5F1B
Tbio
Family:  Enzyme
Novelty:  0.01053177
p_int:  0.997277101
p_ni:  0.002722899
Score:  0.999
Data Source:  BioPlex,STRINGDB
GHDC
Tbio
Novelty:  0.08423152
p_int:  0.982687156
p_ni:  0.017312838
p_wrong:  6e-9
Score:  0.19
Data Source:  BioPlex,STRINGDB
ATP5F1D
Tbio
Family:  Enzyme
Novelty:  0.07296539
p_int:  0.864935249
p_ni:  0.135064751
Score:  0.997
Data Source:  BioPlex,STRINGDB
GOLGA4
Tbio
Novelty:  0.01363253
p_int:  0.815145796
p_ni:  0.184818558
p_wrong:  0.000035647
Score:  0.187
Data Source:  BioPlex,STRINGDB
ATP5PB
Tbio
Family:  Enzyme
Novelty:  0.07345384
Score:  0.999
Data Source:  STRINGDB
ATP5MC1
Tbio
Family:  Enzyme
Novelty:  0.03538978
Score:  0.999
Data Source:  STRINGDB
ATP5F1A
Tbio
Family:  Enzyme
Novelty:  0.01052213
Score:  0.998
Data Source:  STRINGDB
ATP5F1C
Tbio
Family:  Enzyme
Novelty:  0.07666564
Score:  0.998
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Cristae formation (R-HSA-8949613)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cristae formation
Reactome
Formation of ATP by chemiosmotic coupling
Reactome
Metabolism
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cristae formation
Formation of ATP by chemiosmotic coupling
Metabolism
Mitochondrial biogenesis
Organelle biogenesis and maintenance
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
9.4
self reported educational attainment
1
1
1
5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
9.4
self reported educational attainment
1
5
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2442035
228033
Rat
RGD:620052
114630
Dog
ATP synthase membrane subunit c locus 3
478807
Horse
ATP synthase membrane subunit c locus 3
VGNC:51436
100053347
Cow
ATP synthase membrane subunit c locus 3
540176
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
ATP synthase membrane subunit c locus 3
Horse
ATP synthase membrane subunit c locus 3
Cow
ATP synthase membrane subunit c locus 3
Publication Statistics
PubMed Score 21.28
PubMed score by year
PubTator Score 70.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title