Tbio IREB2 Iron-responsive element-binding protein 2

Protein Summary

Description

RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• P48200
• A0A0A6YY96
• A8KAC7
• E1CJT9
• H0YKU0
• Q13095
• Q1HE21
• Q59FQ7
• Q8WVK6
• Q9UF17
• IRE-BP 2

Gene Name

• IREB2

Ensembl ID

• ENST00000258886
• ENSP00000258886
• ENSG00000136381
• ENST00000560440
• ENSP00000452938

Symbol

• ACO3
• IRP2
• IRP2AD
• IRE-BP2
• IRE-BP 2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
virus perturbation	0.88
biological process	0.84
transcription factor binding site profile	0.84
disease perturbation	0.83

Protein Classes

PANTHER Classes

Protein / Lyase / Hydratase / Iron-responsive Element-binding Protein 2

Protein / Lyase / Dehydratase / Iron-responsive Element-binding Protein 2

DTO Classes

Protein / Enzyme / Lyase / Dehydratase / Iron-responsive Element-binding Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 420.62   (req: < 5)

Gene RIFs: 53   (req: <= 3)

Antibodies: 317   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 420.62   (req: >= 5)

Gene RIFs: 53   (req: > 3)

Antibodies: 317   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0