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Tclin
GLRB
Glycine receptor subunit beta

Protein Classes
Protein Summary
Description
Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed:8717357). Plays an important role in the down-regulation of neuronal excitability (PubMed:11929858, PubMed:23238346). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause star ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264428
  • ENSP00000264428
  • ENSG00000109738
  • ENST00000509282
  • ENSP00000427186
  • ENST00000541722
  • ENSP00000441873

Symbol
  • HKPX2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
virus perturbation
0.76
protein domain
0.73
PubMedID
0.73
histone modification site profile
0.69


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.86   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.86   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycine receptor beta
VGNC:2007
461569
Macaque
glycine receptor beta
700368
Mouse
MGI:95751
14658
Rat
RGD:2706
25456
Dog
glycine receptor beta
VGNC:41272
475477
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycine receptor beta
Macaque
glycine receptor beta
Mouse
Rat
Dog
glycine receptor beta
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P48167-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Transmission across Chemical Synapses
Gene Ontology Terms (34)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (174)
1 – 10 of 174
BTNL8
Tdark
Novelty: 0.40339869
p_int: 0.999810777
p_ni: 0.000189141
p_wrong: 8.3e-8
Score: 0.197
Data Source: BioPlex,STRINGDB
TCTN2
Tbio
Novelty: 0.11617528
p_int: 0.999803439
p_ni: 0.000196561
p_wrong: 1e-9
Data Source: BioPlex
GRIA3
Tclin
Family: IC
Novelty: 0.00584546
p_int: 0.999113019
p_ni: 0.000886937
p_wrong: 4.5e-8
Score: 0.492
Data Source: BioPlex,STRINGDB
GP9
Tbio
Novelty: 0.00365769
p_int: 0.998537705
p_ni: 0.001360924
p_wrong: 0.000101371
Data Source: BioPlex
TMPRSS11B
Tdark
Family: Enzyme
Novelty: 1.20690443
p_int: 0.996679222
p_ni: 0.002948357
p_wrong: 0.000372421
Data Source: BioPlex
SLC22A2
Tchem
Family: Transporter
Novelty: 0.00439263
p_int: 0.996282396
p_ni: 0.002219078
p_wrong: 0.001498526
Data Source: BioPlex
CLEC2D
Tbio
Novelty: 0.02501194
p_int: 0.994409799
p_ni: 0.005009832
p_wrong: 0.000580369
Data Source: BioPlex
HYOU1
Tbio
Novelty: 0.00833649
p_int: 0.993399163
p_ni: 0.005588598
p_wrong: 0.001012239
Data Source: BioPlex
GABRA3
Tclin
Family: IC
Novelty: 0.02180091
p_int: 0.993368449
p_ni: 0.006576581
p_wrong: 0.00005497
Score: 0.642
Data Source: BioPlex,STRINGDB
NEMP1
Tdark
Novelty: 0.37603456
p_int: 0.993181067
p_ni: 0.006421302
p_wrong: 0.000397631
Score: 0.179
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  48.86

PubMed score by year
PubTator Score  30.64

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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